Application of trapa acornis nakai shell extract to preparation of medicaments for protecting livers

A technology of extract and water chestnut shell, which is applied in the field of Nanhu water chestnut shell extract and its extraction, can solve the problem that Nanhu water chestnut shell has no protective effect on liver damage, etc.

Active Publication Date: 2012-01-18
金湖县项目服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported in the literature that the water extract of water chestnut shell has anti-aging effects, but there is no research on the protective effect of Nanhu water chestnut shell on liver damage

Method used

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  • Application of trapa acornis nakai shell extract to preparation of medicaments for protecting livers
  • Application of trapa acornis nakai shell extract to preparation of medicaments for protecting livers

Examples

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Embodiment 1

[0013] A Nanhu water chestnut extract, which is selected from the ethyl acetate part and / or n-butanol part of the Nanhu water chestnut alcohol extract; the Nanhu water chestnut extract is extracted by the following method: take 1000 g of dried Nanhu Water chestnut shell, soaked in 80V% methanol aqueous solution (the amount of methanol aqueous solution added is 3-5 times the weight of Nanhu water chestnut shell powder) at room temperature after crushing for 3 times, each time for 3 days, combined the three obtained infusions and concentrated into an extract ; Disperse the extract in 1000ml of distilled water, then extract the extract with the solvent petroleum ether (3000ml), ethyl acetate (3000ml) and n-butanol (3000ml) successively, and extract each three times; after evaporating the solvent, the solids are respectively obtained 37.36 g of the petroleum ether part (TAPE), 198.72 g of the ethyl acetate part (TAEA) and 142.25 g of the n-butanol part (TABU), and the corresponding...

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Abstract

The invention relates to a trapa acornis nakai shell extract, which is selected from an ethyl acetate fraction and/or an n-butanol fraction of a trapa acornis nakai shell alcohol extract. A method for preparing the trapa acornis nakai shell extract comprises the following steps of: crushing a dried trapa acornis nakai shell, leaching by using a methanol aqueous solution, and concentrating leachate to obtain extractum; dispersing the extractum in distilled water, extracting the extractum by using petroleum ether, ethyl acetate and n-butanol which serve as solvents sequentially, and volatilizing the solvents to obtain a petroleum ether fraction, the ethyl acetate fraction and the n-butanol fraction, wherein the extractum is extracted by using each solvent for three times. Experiments prove that the extracts at the ethyl acetate fraction and the n-butanol fraction of the trapa acornis nakai shell can reduce the content of glutamate pyruvate transaminase (GPT) and glutamic-oxalacetic transaminease (GOT) in blood serum of acute liver injury mice and the content of malonaldehyde (MDA) in liver tissue of the mice obviously and improve the activity of superoxide dismutase (SOD) obviously,and can be used for preparing medicaments for protecting livers and particularly medicaments for protecting acute liver injury.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a Nanhu water chestnut shell extract and an extraction method thereof. The Nanhu water chestnut shell extract has liver-protecting effects. It can be used to prepare drugs for protecting acute liver injury. Background technique [0002] Liver injury is a complex process caused by multiple etiologies and involving multiple factors. Liver disease caused by liver injury has become a common and frequently-occurring disease. What is more serious is the liver failure and hepatic encephalopathy caused by it. The morbidity and mortality are high, which greatly threatens human health. Many factors can cause liver injury, and the in vivo model, especially the chemical liver injury model, is similar to human chronic liver disease in some aspects of morphology and pathophysiology. intraperitoneal injection of CCl 4 Vegetable oil solution is currently a commonly used hepatitis model. CCl 4 The mech...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P1/16
Inventor 康文艺李园园黄嬛
Owner 金湖县项目服务中心
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