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Preparation method of dressing for treating burn combined with moist burn cream

A burn ointment and moisturizing technology, applied in the field of biomedical materials, can solve difficult problems such as increasing collagen synthesis, reducing continued damage, and good softness

Active Publication Date: 2012-02-22
上海美宝生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When cleaning liquefied substances and necrotic tissue, the principle should be to not cause pain to the patient, not to bleed from the wound, and not to damage normal tissues, but it is often difficult to achieve this in the actual operation process.

Method used

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  • Preparation method of dressing for treating burn combined with moist burn cream
  • Preparation method of dressing for treating burn combined with moist burn cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 1g of sodium hyaluronate and 0.5g of sodium carboxymethylcellulose in a beaker, add 100ml of distilled water, stir gently until the solute is fully dissolved, use hydrochloric acid to adjust the pH of the solution to 4.5, and add 10% of the solution dropwise 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), while adding and stirring, monitor the pH value of the solution at all times, and adjust the pH value at 4.5 with hydrochloric acid solution at any time -4.8 range. After the added EDC solution reaches 5ml, stop adding, stir evenly, and place at room temperature at 25°C for 4h. Add 1.0g of sodium chloride to the solution to dissolve it, then add 350ml of 95% ethanol, add while stirring to form a flocculent precipitate, let stand overnight, collect the precipitate, add 50ml of absolute ethanol, and leave it at room temperature after stirring 4 For hours, repeat the operation of "collecting the precipitate, adding 50ml of absolute ethanol, leavi...

Embodiment 2

[0042] Weigh 0.8 sodium hyaluronate and 1.0 hydroxyethyl cellulose sodium in a beaker, add 100ml of distilled water, stir gently until the solute is fully dissolved, use acetic acid solution to adjust the pH to 4.7, and add 10% distilled water dropwise to the solution. Methylaminopropyl ethyl carbodiimide is added while stirring, while monitoring the pH value of the solution at all times, and adjust the pH value in the range of 4.5-5.0 with acetic acid solution at any time. After the added carbodiimide solution reaches 10ml, stop adding, stir evenly, and place at 30°C for 4h. Add 0.9g of sodium chloride to the solution to dissolve it, add 350ml of 95% ethanol, add while stirring to form a flocculent precipitate, let it stand overnight, collect the precipitate, add 100ml of absolute ethanol, and leave it at room temperature after stirring. For hours, repeat the operation of "collecting the precipitate, adding 100ml of absolute ethanol, leaving it at room temperature for 6 hours ...

Embodiment 3

[0044] Weigh 2.0 g of sodium hyaluronate and 0.2 g of sodium carboxymethyl cellulose in a beaker, add 100 ml of distilled water, stir gently until the solute is fully dissolved, adjust the pH value of the sulfuric acid solution to 5.0, and add 10% of the solution dropwise 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), while adding and stirring, monitor the pH of the solution at all times, and use sulfuric acid solution to adjust the pH to 5.0 at any time -5.5 range. After the added carbodiimide solution reaches 10ml, stop adding, stir evenly, and place at 30°C for 4h. Add 1.1g of sodium chloride to the solution to dissolve it, add 500ml of 95% ethanol, add while stirring to form a flocculent precipitate, let stand overnight, collect the precipitate, add 70ml of absolute ethanol, leave it for 2 hours, repeat "Collect the precipitate, add 70ml of absolute ethanol, let it stand for 2 hours, and collect the precipitate" 5 times, squeeze the ethanol out, and va...

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Abstract

The invention provides a preparation method of dressing for treating burn combined with moist burn cream, which includes (1) dissolving hyaluronic acid and cellulose derivative in distilled water and regulating the pH value to be acidity; (2) adding cross linking agent in the solution in dropwise mode to conduct cross-linking reaction; (3) conducting ethanol precipitation, using ethanol to washing precipitate repeatedly and drying the precipitate in vacuum; and (4) swelling the dried precipitate in water solution containing zinc ions, freezing, drying and pressing the mixture to obtain the slice dressing. The dressing prepared in the method has grease scattering performance when treating the burn combined with the moist burn cream, cannot affect treating effect caused by the fact that the dressing absorbs ointment of the moist burn cream, simultaneously is capable of being attached to the surface of burnt skin to form a loose separation layer which is good in air permeability and capable of absorbing burn surface transduate, can effectively protect and close the burn surface to reduce scab area, and has functions of restraining scar tissue generation and accelerating burn surface union. The dressing enables dressing change to be easy to operate and cannot damage burn surface tissue due to flexibility and globality.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a preparation method of a dressing combined with moist burn ointment for treating burns. Background technique [0002] Burns are one of the common diseases in surgery. According to statistics, burns are second only to traffic accidents in the number of deaths due to accidental injuries each year. The annual incidence of burns in my country is about 1.5% to 2%, that is, about 20 million people suffered burns of varying degrees, and about 5% of burn patients required hospitalization. For moderate and severe burns, a combination of systemic and local treatments is required. For wounds, in addition to preventing infection, it is necessary to promote their healing as soon as possible. At present, there are many ointments or dressings used for local treatment of burn wounds, among which traditional Chinese medicine ointment is a relatively effective treatment method. Our previous p...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44C08J3/24
Inventor 商庆新葛翠兰徐荣祥
Owner 上海美宝生命科技有限公司
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