Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing D-calcium erythorbate

A technology of erythorbic acid and calcium ascorbate, applied in directions such as organic chemistry, can solve problems such as rare application reports of D-calcium ascorbate, no public reports on D-calcium ascorbate synthesis, and achieve stable quality, mild reaction conditions, and technology. Easy to use effect

Inactive Publication Date: 2012-03-14
江西省德兴市百勤异VC钠有限公司 +1
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are a few reports about the preparation method of L-calcium ascorbate, but there is no public report about the synthesis of D-calcium ascorbate, and there are few application reports involving D-calcium ascorbate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] At room temperature, 180.0 g of D-erythorbic acid was dissolved in 1200 mL of distilled water, and 46.0 g of light calcium carbonate was slowly added under stirring for neutralization. After the reaction solution turns into a transparent solution, centrifuge (4000r / min, 20min) to remove a very small amount of insoluble impurities. Use a rotary evaporator to concentrate the filtrate under reduced pressure to a syrupy state, add it to 2000 mL of anhydrous methanol, stir slowly for 2 h, and filter to obtain a wet product of calcium D-erythorbate. The wet product of calcium D-erythorbate was dried under reduced pressure for 8 hours to obtain 169.7 g of finished calcium D-erythorbate. The yield is 84.50% of the theoretical yield, and the product purity is 99.31%.

Embodiment 2

[0013] At room temperature, 175.0 g of D-erythorbic acid was dissolved in 1150 mL of distilled water, and 45.0 g of light calcium carbonate was slowly added under stirring for neutralization. After the reaction solution turned into a transparent solution, a small amount of insoluble impurities was removed by suction filtration. Concentrate the filtrate under reduced pressure with a rotary evaporator to a syrupy state, add it to 2000 mL of absolute ethanol, stir slowly for 2.5 h, and filter to obtain a wet product of calcium D-erythorbate. The wet product of calcium D-erythorbate was dried under reduced pressure for 8 hours to obtain 165.4 g of finished calcium D-erythorbate. The yield is 84.17% of the theoretical yield, and the product purity is 98.67%.

Embodiment 3

[0015] At room temperature, 175.0 g of D-erythorbic acid was dissolved in 1150 mL of distilled water, and 27.5 g of calcium oxide was slowly added under stirring for neutralization. After the reaction solution turns into a transparent solution, centrifuge (4000r / min, 20min) to remove a very small amount of insoluble impurities. Concentrate the filtrate under reduced pressure with a rotary evaporator to a syrupy state, add it to 1600 mL of anhydrous methanol, stir slowly for 2 h, and filter to obtain a wet product of calcium D-erythorbate. The wet product of calcium D-erythorbate was dried under reduced pressure for 10 hours to obtain 163.6 g of finished calcium D-erythorbate. The yield is 83.14% of the theoretical yield, and the product purity is 98.54%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing D-calcium erythorbate by taking D-erythorbic acid as a raw material. The method comprises the following steps of: dissolving D-erythorbic acid into water, and neutralizing D-erythorbic acid by adopting CaCO3, CaO or Ca(OH)2 which is 0.4-0.5 time the molar weight of the D-erythorbic acid, wherein the reacting temperature is at 5-6 DEG C; filtering and removing insoluble impurities from a neutralizing liquid, and concentrating a filtrate to slurry state under reduced pressure; and adding absolute methanol or absolute ethanol into slurry till the volume of the absolute methanol or absolute ethanol accounts for over 90 percent of the total volume of the mixed solution, slowly stirring till crystals are separated out, filtering to obtain wet D-calcium erythorbate, and drying to obtain finished D-calcium erythorbate. The yield of the D-calcium erythorbate prepared with the method is over 83 percent, and the purity is over 98 percent.

Description

technical field [0001] The invention provides a method for preparing calcium D-erythorbate by using D-erythorbic acid as a raw material, which belongs to the field of fine chemical industry. Background technique [0002] D-erythorbic acid is an optical isomer of L-ascorbic acid (vitamin C), which has strong reducibility. D-erythorbic acid is similar to vitamin C in chemical properties, and has better antioxidant properties than vitamin C. The US Food and Drug Administration (FDA) has listed D-erythorbic acid as a generally recognized safe substance. In terms of physiological effects, although the antiscorbic effect of D-erythorbic acid is only 1 / 20 of that of vitamin C, its effects of lowering blood pressure, diuresis, detoxification, promoting liver glycogen production and pigment excretion are almost the same as vitamin C . [0003] At present, there are a few reports about the preparation method of L-calcium ascorbate, but there is no public report about the synthesis o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D307/62
Inventor 余泗莲周强余彬孙文敬方翔林岚崔凤杰
Owner 江西省德兴市百勤异VC钠有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com