NaYF4-based fluorescent nano particles with double effects and preparation method thereof

A fluorescent nanoparticle, dual-action technology, applied in the field of NaYF4-based fluorescent nanoparticle and its preparation, to achieve the effect of increasing fluorescence intensity, good application prospects, and good up-conversion fluorescence emission

Inactive Publication Date: 2012-03-28
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By submitting to NaYF 4 Doping the rare earth element Gd ions in the matrix can make the material have T 1 -MRI contrast features, however, currently Gd 3+ Doped NaYF 4 The highest reported structure r 1 value of only 1.4 mM -1 the s -1 (Park, Y. I. and Hyeon, T. Adv. Mater. 2009 , 21, 4467.), far lower than clinical Gd agents, therefore, it is urgent to develop a more efficient NaYF-based 4 Fluorescence / magnetic resonance dual-mode nano-biomolecular probes

Method used

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  • NaYF4-based fluorescent nano particles with double effects and preparation method thereof
  • NaYF4-based fluorescent nano particles with double effects and preparation method thereof
  • NaYF4-based fluorescent nano particles with double effects and preparation method thereof

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preparation example Construction

[0049] (2) Preparation of two-layer core-shell structure: NaYF 4 :Er / YbGdNaYF 4 :Tm / Yb

[0050] 1) Aqueous solution of rare earth chlorides: weigh appropriate amounts of chlorides of yttrium (Y), ytterbium (Yb), and thulium (Tm), and dissolve them in deionized water for later use. Rare earth chlorides can use their respective commonly used hydrates, such as YCl 3 ·6H 2 O, YbCl 3 ·6H 2 O, TmCl 3 ·6H 2 O. The amount of deionized water employed may be that which dissolves the chloride or a slight excess.

[0051] 2) Add the above-mentioned pre-configured aqueous solution of rare earth chloride to the mixture of oleic acid and octadecene. The volume ratio of oleic acid and octadecene used can be 1:2, and stirred at room temperature for about 1 hour. Argon gas is passed for a certain period of time (for example, 5 minutes) to remove air, followed by a slow water removal process. After the water removal is completed, the temperature of the system rises to about 160°C and ...

Embodiment 1

[0064] The NaYF of embodiment 1 average particle size 18 nm 4 : Preparation of Er / Yb / Gd:

[0065] Rare earth chloride aqueous solution: weigh 1.3 mmol (394.368 mg) of YCl respectively 3 ·6H 2 O, 0.36 mmol (139.4964 mg) of YbCl 3 ·6H 2 O, 0.04 mmol (15.2684 mg) of ErCl 3 ·6H 2 O and 0.3mmol (79.083) of GdCl 3 ·xH 2 O powder, dissolved in 4 mL deionized water for later use.

[0066] Add 15 mL of oleic acid and 30 mL of octadecene into the three-necked flask, and then add the above-mentioned aqueous chloride solution prepared in advance, and stir at room temperature for 1 hour. Pass argon for 5 minutes to remove the air in the bottle, and then the system begins to slowly remove water. After the water removal is completed, the system is raised to about 160°C and kept for 60 minutes. A pale yellow clear liquid is obtained. Heating was stopped, and the system was allowed to cool down to room temperature naturally (during which argon gas was kept flowing).

[0067] Weigh ...

Embodiment 2

[0071] Example 2 (preparation of NaYF4:Er / Yb / Gd NaYF4:Tm / Yb with an average particle size of 22 nm):

[0072] On the basis of embodiment 1, proceed to the following steps:

[0073] Rare earth chloride aqueous solution: weigh 0.747 mmol (226.61 mg) of YCl 3 ·6H 2 O, 0.25 mmol (96.8725 mg) of YbCl 3 ·6H 2 O, 0.003 mmol (0.8258 mg) of TmCl 3 ·6H 2 O powder, dissolved in 4 mL deionized water for later use.

[0074] Add 15 mL of oleic acid and 30 mL of octadecene into the three-necked flask, then add the pre-prepared aqueous chloride solution, and stir at room temperature for 1 hour. Argon was passed for 5 minutes to remove the air in the bottle, and then the system began to slowly remove water. After the water removal is completed, the system is raised to about 160°C and kept for 60 minutes. A pale yellow clear liquid is obtained. Stop heating, let the system cool down to room temperature naturally (keep argon flowing).

[0075] In the system, add the NaYF prepared by th...

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Abstract

The invention relates to NaYF4-based fluorescent nano particles with double effects and a preparation method thereof. The NaYF4-based fluorescent nano particles at least comprise a kernel and a shell, wherein the kernel is NaYF4: Er / Yb / Gd or NaYF4: Er / Yb, and the shell is NaGdF4. By introducing different luminous ion pairs into different layers, the single-excitation multi-color luminescence function of the single fluorescent particles is realized, and the fluorescent particles have magnetic resonance imaging function; and meanwhile, by introducing a wrapping layer, surface defects of the particles are reduced, and the fluorescent strength of the particles is improved.

Description

technical field [0001] The invention relates to the field of up-conversion fluorescent materials, in particular to a NaYF with dual modes of up-conversion fluorescence imaging and magnetic resonance imaging 4 Fluorescent nanoparticles and methods for their preparation. Background technique [0002] Early diagnosis of tumors urgently needs a biological probe with multiple mode combination, high efficiency and specific active targeting. Fluorescence imaging and magnetic resonance imaging are currently the most promising diagnostic modalities. The study of multimodal probes based on fluorescence / magnetic resonance composites is expected to overcome many deficiencies in the current early diagnosis of cancer and improve the diagnosis rate of clinical tumors. At present, the research focus in the field of traditional fluorescence imaging is based on organic fluoresceins and semiconductor quantum dots containing heavy metal elements. The former is gradually replaced by the latte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85A61K49/00
Inventor 陈风步文博施剑林
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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