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Chitin-modified gold nanocolumn and its manufacturing method

A technology of gold nanocolumn and manufacturing method, which is applied in the field of gold nanocolumn and its manufacturing, can solve the problems of cytotoxicity, complex environment, unfavorable popularization and application of gold nanocolumn, and achieve the effect of improving biocompatibility

Active Publication Date: 2015-09-16
TAIWAN HOPAX CHEM MFG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method has been confirmed by in vitro cell experiments to have the effect of masking the cytotoxicity of cetyltrimethylammonium bromide, however, the environment in vivo is often more complex and unpredictable than in vitro, so it cannot be excluded in vivo. In vivo use, there is still a risk of cytotoxicity due to exposed cetyltrimethylammonium bromide
In addition, the price of sodium polystyrene sulfonate is too high, which is not conducive to the popularization and application of gold nanopillars in biomedicine.

Method used

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  • Chitin-modified gold nanocolumn and its manufacturing method
  • Chitin-modified gold nanocolumn and its manufacturing method
  • Chitin-modified gold nanocolumn and its manufacturing method

Examples

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preparation example Construction

[0030] "Preparation of chitin-gold nanopillars"

[0031] The preparation method of the chitin-gold nanocolumn described in the present invention comprises: at first providing a 1-10wt% chitin solution and a solution containing the gold nanocolumn modified by polyalkyltrimethylammonium bromide, and Mix evenly to form a mixture.

[0032] Next, the mixed solution is left standing at 20-30° C. to form a chemical bond between the chitin and the gold nanocolumn; more specifically, the amino group of the chitin forms a chemical bond with the gold nanocolumn , and the chitin is used as a substituent to replace the polyalkyltrimethylammonium bromide originally modified on the gold nanocolumn. Preferably, an acid solution is further added to the mixed solution as a leaving agent of the polyalkyltrimethylammonium bromide to promote the substitution reaction of chitin; preferably, the leaving agent accounts for 1-5% (v / v) of the mixed solution.

[0033] The "polyalkyltrimethylammonium ...

Embodiment 1

[0036] Embodiment 1: the preparation of chitin-gold nanocolumn of the present invention

[0037] After the pH value of a chitin solution with a concentration of 1wt% was adjusted to pH=2 by hydrochloric acid, it was mixed with a gold nanocolumn modified with hexadecyltrimethylammonium bromide (such as Figure 1A Shown) the solution is uniformly mixed into a mixed solution.

[0038] Next, after adding 3 wt % hydrochloric acid as a leaving agent, the mixed solution was allowed to stand at room temperature for 6 hours.

[0039] Finally, the mixed solution was centrifuged at 10000rpm for 3 times to separate the crystals in the mixed solution to obtain the chitin-gold nanocolumn of this embodiment (such as Figure 1B shown).

[0040] Compare Figure 1A and Figure 1B , showing that according to the method of the present invention, substituting chitin for cetyltrimethylammonium bromide to prepare chitin-gold nanocolumns will not change the appearance and shape of the original gold...

Embodiment 2

[0041] Embodiment 2: identification chitin-gold nanocolumn of the present invention

[0042] Firstly, the standard absorption peak positions of the cetyltrimethylammonium bromide-modified gold nanocolumns and the chitin-gold nanocolumns obtained in Example 1 were observed by ultraviolet-visible light spectroscopy.

[0043] Please refer to figure 2 , Curve A shows that the short-axis absorption peak of cetyltrimethylammonium bromide-modified gold nanopillars is 530 nm, while the long-axis absorption peak is 690 nm. Curve B shows the short-axis and long-axis absorption peaks of chitin-gold nanopillars. Overall, the absorption wavelength of chitin-gold nanopillars did not change significantly, and the peak shape was not far from the same.

[0044] Then, confirm the bonding relationship between the gold nanocolumn and the amino group of chitin in the method of the present invention. Please refer to image 3 , where Curves A and B are the infrared spectra (IR) of the chitin-gold...

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Abstract

The invention relates to a gold nanorod and a manufacturing method thereof. The manufacturing method comprises the following steps of: a, providing a mixed solution which comprises chitosan and a multi-alkyl trimethyl ammonium bromide-modified gold nanorod; b, chemically bonding the chitosan with the gold nanorod; and c, centrifuging to obtain a chitosan-modified gold nanorod. In the method, multi-alkyl trimethyl ammonium bromide is replaced by the chitosan, so that the aim of improving the biocompatibility of the gold nanorod is fulfilled.

Description

technical field [0001] The invention relates to a nanometer material and a manufacturing method thereof, in particular to a gold nanocolumn and a manufacturing method thereof. Background technique [0002] The unique properties of nanomaterials (such as optical, electrical, and magnetic properties) are mainly related to their size and shape. In recent years, research on nanomaterials has flourished and has been gradually applied in various fields, such as wastewater purification, antibacterial coatings, cell imaging technology and anti-cancer technology, etc. [0003] The application of gold nanomaterials in cell medicine is very forward-looking. With the change of appearance, the surface plasmon resonance absorption position of gold nanomaterials will also change, and the longest absorption wavelength can be as long as the wavelength range of infrared rays. Due to the strong penetrating power of infrared rays, gold nanomaterials can absorb infrared rays. Potential for the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/00
Inventor 黄景弘赖宗庆郑良谦刘如熹萧宏升何丽贞颜尧德
Owner TAIWAN HOPAX CHEM MFG