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Cefaclor solution and preparation method thereof

A technology of cefaclor and solution, which is applied in the field of cefaclor solution and its preparation, can solve the problems of inconvenient administration and poor water solubility, and achieve the effect of convenient administration and high bioavailability

Inactive Publication Date: 2012-04-11
上海恒丰强生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] An object of the present invention is to provide cefaclor solution, to overcome the poor water solubility of existing cefaclor dosage forms, defects such as inconvenient administration

Method used

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  • Cefaclor solution and preparation method thereof
  • Cefaclor solution and preparation method thereof
  • Cefaclor solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The cefaclor solution, calculated by weight percentage, is mainly made of cefaclor as the main ingredient and mixed with an appropriate amount of glycerol.

[0019] Recipe and method:

[0020] Cefaclor 5%

[0021] Glycerol 95%.

[0022] production method

[0023] (1) Dissolving the cefaclor weighed as required with an appropriate amount of glycerol in preparation in advance;

[0024] (2) Add glycerin to the full amount, continue to stir to make it evenly mixed, and then test the test after stirring the liquid medicine evenly;

[0025] (3) After passing the inspection, it is filled and sealed under the condition of stirring, and then labeled, packaged, randomly inspected, and put into storage.

Embodiment 2

[0027] The research data and results of stability experiments, accelerated and long-term experiments are as follows.

[0028] Test sample

[0029] Sample name: Cefaclor solution

[0030] Sample requirements: 3 batches, simulating commercial packaging

[0031] Sample specification: 100:5g

[0032] Sample batch number: respectively (100mL:5g)

[0033] 20080302, 20080304, 20080306

[0034] (50ml:2.5g)

[0035] 20060301, 20060302, 20060303

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PUM

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Abstract

The invention discloses a cefaclor solution, comprising the following raw materials in weight percentage: 5% of cefaclor and 95% of alcohol solvents. The invention further discloses a preparation method of the cefaclor solution. The cefaclor is dissolved by adopting an organic solvent, and the cefaclor is existent in solution form and dosed by oral solution manner. The cefaclor has high lipid solubility and low premix dissolution rate, and is terribly hard to be dissolved in water and common organic solvents; after the cefaclor is developed into the solution form through a pharmaceutics method, the dosing is convenient, and the bioavailability is high.

Description

technical field [0001] The invention relates to a cefaclor solution and a preparation method thereof. Background technique [0002] Cefaclor is a second-generation oral cephalosporin, which has a strong killing effect on a variety of Gram-positive and Gram-negative bacteria. It is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is higher than that of cefadroxil 2 to 4 times stronger. The activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than cephalexin, similar to cefadroxil, and the activity against Proteus mirabilis, Salmonella and Shigella is stronger than cefadroxil . Inhibits all Haemophilus influenzae, including ampicil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/545A61K47/10A61P31/04
Inventor 廖洪李敏宋莉高建辉
Owner 上海恒丰强生物技术有限公司