Microbeam multi-channel parallel surface plasmon resonance detection system
A detection system and micro-beam technology, which are applied in measurement devices, measurement of scattering characteristics, material analysis by optical means, etc., can solve the problem that the SPR sensor chip reader is large in size, and the miniaturized SPR clinical detection system is blank and cannot be applied. problems in the field of miniaturized SPR clinical detection systems to achieve high detection throughput and high clinical biological testing results
Inactive Publication Date: 2012-04-18
BEIJING GP MEDICAL TECH
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However, the SPR sensor chip reader has a large volume and cannot be applied to the field of miniaturized SPR clinical detection systems.
At present, the miniaturized SPR clinical detection system suitable for batch screening is still blank
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[0024] The present invention will be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments of the invention are illustrated.
[0025] figure 1 A schematic structural diagram of a micro-beam detection system provided by an embodiment of the present invention is shown.
[0026] Such as figure 1 As shown, the micro-beam detection system includes: a rotating shaft 12, which is used to generate a deflection angle for the beam projected by the light source 11, and projects it to a symmetrical optical system for detecting SPR; a symmetrical optical system, which is used to converge the beam projected by the rotating shaft 12 to the SPR on the sensor chip 15 , and converge the light beam reflected by the SPR sensor chip 15 to the photodiode 17 .
[0027] In an embodiment of the micro-beam detection system provided by the present invention, the rotation axis 12 is selected from any one of a plane mirror, a prism, a convex mirror ...
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The invention discloses a microbeam multi-channel parallel surface plasmon resonance detection system, which contains a chip box 4 which is a SPR sensor chip assembly formed by a plurality of SPR sensor chips 15 arranged side by side, and an optical system 1 which is formed by a plurality of microbeam scanning units which are arranged in parallel with each other, wherein the microbeam scan units are selected from any one microbeam detection system in the invention. The microbeam multi-channel parallel surface plasmon resonance detection system provided by the invention can be used to realize high-throughput and miniaturization detection requirements. In addition, in allusion to specific biological diseases, specific biological probes are coated on the SPR sensor chip assembly, and detection conditions and detection flow are fixed. Therefore, clinical biological testing with high detection throughput can be realized without artificial intervention.
Description
technical field [0001] The invention relates to the technical field of biological detection, in particular to a micro-beam detection system and a surface plasmon resonance (SPR, Surface Plasma Resonance) detection system with multiple parallel micro-beams. Background technique [0002] In recent years, surface plasmon resonance detection technology has developed extremely rapidly, and has become an important means for the analysis of molecular interactions; especially in the field of analysis of biological interactions, it has become an important research tool for biochemical laboratories. At present, a variety of commercialized SPR detection and analysis instruments have been launched on the market; such SPR detection and analysis instruments are mainly developed for the characteristics of "diversification of tested samples, diversification of detection and analysis purposes, and diversification of detection and analysis processes". However, the experimental conditions and ...
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IPC IPC(8): G01N21/55G01N21/552
Inventor 江先玉高赞军杜国军张海青王艳丽吴晓东
Owner BEIJING GP MEDICAL TECH