Self-microemulsion and preparation method thereof

A self-microemulsion, selected technology, applied in the field of microemulsion, can solve the problems such as the lack of a clear description of the temperature stability range of the final product, stability defects, etc., and achieve wide geographical applicability and transportation stability, good applicability, excellent The effect of stability

Active Publication Date: 2012-04-25
XIAMEN KINGDOMWAY BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 200710304523.5 discloses that the coenzyme Q10 nano-microcapsule emulsion also adopts a high-pressure homogenization method, and there is no clear description of the temperature stability range of the final product
However, the preparation method based on external energy supply has certain defects in its stability.

Method used

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  • Self-microemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of DHA self-microemulsion

[0033] The DHA self-microemulsion was prepared according to the following operations by using the following components by mass: DHA oil was added to the vegetable oil, and then the oil phase emulsifier was added, and then heated and stirred evenly after evacuating nitrogen for three times; then adding a quantitative co-emulsifier glycerin, Add the main emulsifier ten polyglycerol monooleate and sodium stearoyl lactylate. The functional substance pullulan is dissolved in quantitative pure water, and finally added to the mixing system. Heat at 60-65°C and stir until the final system is uniform and transparent, keep it warm for 10-30 minutes, and get the final product after cooling down to room temperature.

[0034] DHA oil: 10-30;

[0035] Sunflower oil (vegetable oil): 5-20;

[0036] Span 80: 1~5;

[0037] Ten polyglycerol monooleate: 15-25;

[0038] Sodium stearoyl lactylate: 1-5;

[0039] Glycerin: 15-25;

[0040] Water: 8~1...

Embodiment 2

[0044] Preparation of ARA self-microemulsion

[0045] The ARA transparent self-microemulsion was prepared by the same operation as described in Example 1, but the following parts by mass of the self-microemulsion system components were used.

[0046] ARA oil: 5-15;

[0047] Sunflower oil (vegetable oil): 5-20;

[0048] Glyceryl monooleate: 1~5;

[0049] Ten polyglycerol monooleate: 15-25;

[0050] Sodium glutamate: 1~5;

[0051] Glycerin: 20-30;

[0052] Water: 8~15;

[0053] Dextran: 0-2.

[0054] The final product obtained is a light yellow transparent and uniform emulsion, in which the ARA oil phase loading is as high as 15%, and has a high oil loading. The content is determined by the method of the national standard GB / T 26401-2011, and the microemulsion preparation with the ARA content between 3% and 15% can be prepared. The emulsion has good stability and can be stored stably in the range of -10-60°C. Take about 1g of this product and add it to 100ml of deionize...

Embodiment 3

[0056] Preparation of coenzyme Q10 self-microemulsion

[0057] Coenzyme Q10 self-microemulsion was prepared according to the following operation by using the following mass fraction components: Add coenzyme Q10 to caprylic glyceride, then add the oil phase emulsifier Span 60, avoid light and pump nitrogen for three times, then heat and stir until solid The material is completely dissolved; then a quantitative co-emulsifier glycerin is added, and then the main emulsifier Tween 60 and sodium stearate are added. The functional substance mannitol is dissolved in quantitative pure water, and finally added to the mixing system. Avoid light and oxygen, heat at about 65°C and stir until the whole system is uniform and transparent, keep it warm for 10-30 minutes, and get the final product after cooling down.

[0058] Coenzyme Q10: 5-20;

[0059] Glyceryl caprylate: 5-20;

[0060] Span 60: 1~5;

[0061] Tween 60: 15-25;

[0062] Sodium stearate: 1-5;

[0063] Glycerin: 20-30;

[...

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Abstract

The invention discloses a self-microemulsion and a preparation method thereof, relates to a microemulsion and provides the self-microemulsion with the advantages of wide regional applicability, stable transmission, wide temperature range, high oil carrying amount and transparency as well as the preparation method thereof. The self-microemulsion consists of the following components in parts by mass: 10-40 parts of oil phase, 0-5 parts of oil phase emulsifying agent, 20-40 parts of main body emulsifying agent, 20-50 parts of assisted emulsifying agent, 5-15 parts of aqueous media, 0-2 parts of functional additive and 20-40 parts of main body emulsifying agent. The preparation method comprises the following steps of: feeding oil-soluble products into stirring equipment; adding carried oil and the oil phase emulsifying agent; mixing and heating the mixture until the mixture is dissolved for later use; adding the main body emulsifying agent, the assisted emulsifying agent, the aqueous media and the functional substance in another stirring equipment; stirring, mixing and heating the mixer until the mixture is dissolved for later use; and adding the dissolved aqueous phase in an oil phase vessel, stirring until the emulsion is transparent and cooling to be normal temperature to obtain a product.

Description

technical field [0001] The invention relates to a microemulsion, in particular to a high oil-carrying transparent self-microemulsion system with a wide application range of temperature preservation and a preparation method thereof. Background technique [0002] The concept of microemulsion (microemulsion) was first proposed by Hoar~H Schulman in 1943. It is a transparent or translucent low-viscosity emulsion spontaneously formed by water phase, oil phase, surfactant and co-surfactant in appropriate proportions. , isotropic and thermodynamically stable solution system. With the rapid development of nanotechnology, the development of new technologies and new dosage forms of microemulsions has been promoted, and the varieties of emulsions have been further enriched. [0003] Nanoemulsion (nanoemulsion) is a colloidal dispersion system formed by dispersing emulsion droplets with a particle size of 10-100nm in another liquid. The emulsion droplets are mostly spherical, relativel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/14A61K47/26A61K47/34A61K47/36A61K47/44
Inventor 陈中科陈武强魏初权
Owner XIAMEN KINGDOMWAY BIOTECH CO LTD
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