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Methionine-deviated peptide mimics and use in protection for mitochondrions of skin cells

A peptide mimetic, skin protection technology, applied in the field of peptide mimetics, can solve problems such as high sensitivity and low skin penetration ability

Inactive Publication Date: 2015-06-03
EXSYMOL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The applicant is more particularly interested in methionine, where the sulfur atom participates in the same thioether functional group (S-CH 3 ), but some properties attached to methionine are contrary to what is sought: odor of sulfur-containing organic derivatives unsuitable for cosmetic / dermatological applications, low skin penetration, and more importantly by methionine food supplements Evidence of generated intramitochondrial ROS and oxidative damage to mitochondrial DNA (Caro P. et al, Rev. -1073)
In addition, oligomethionine-type peptides (dimethionine, trimethionine, etc.) are predicted to be hypersensitive to skin proteases

Method used

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  • Methionine-deviated peptide mimics and use in protection for mitochondrions of skin cells
  • Methionine-deviated peptide mimics and use in protection for mitochondrions of skin cells
  • Methionine-deviated peptide mimics and use in protection for mitochondrions of skin cells

Examples

Experimental program
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preparation example

[0067] Formula A (Cream)

[0068]

[0069]

[0070] Formulation B (Gel)

[0071]

[0072] Formulation C (capsule, oral administration)

[0073] N-Acetyl-(DL)-methionyl-4-(methylthio)propylamine (200mg powder / capsule)

[0074] or

[0075] N-4-(methylthio)-butyryl-L-methionine methyl ester (200mg powder / capsule)

[0076] Excipients to fill one gelatin capsule: microcrystalline cellulose, magnesium stearate.

Embodiment 2

[0078] Purely by way of example, in the following the invention is elucidated by means of the following tests (Test 1 to Test 6) already mentioned above in the description of the invention. It should also be noted that in vivo studies are ongoing and preliminary results may also clarify the utility of some of the methionine-derived peptidomimetics of the present invention.

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Abstract

The present invention relates to methionine-deviated peptide mimics and use in protection for mitochondrions of skin cells. The invention relates to a group of peptide mimics which are selected and are deviated from methionine amino acid, and to the use of the peptide mimics as protection agents for the mitochondrions of the skin cells. The invention also relates to a cosmetic composition or dermatopathology composition for preventing and treating skin diseases which are related with mitochondrion dysfunction.

Description

technical field [0001] The present invention relates to a selected group of peptidomimetics derived from the amino acid methionine and their use as mitochondrial protectants for skin cells. The invention also relates to compositions intended to prevent or combat skin disorders associated with mitochondrial dysfunction. Background technique [0002] As cytoplasmic organelles present in plant cells and animal cells, mitochondria play a vital role in these cells. In fact, mitochondria are known as the "energy powerhouses of the cell" because they produce and store adenosine triphosphate (ATP), the universal energy component required by all eukaryotic cells to function. [0003] In the above-mentioned production, which takes place through a series of redox chemical reactions (commonly referred to as the "mitochondrial respiratory chain"), the requisite combustion aid is oxygen. Oxygen is therefore essential for the functioning of cells, but paradoxically, oxygen is also the so...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C323/60A61K31/198A61P17/16A61K8/44A61Q17/04A61Q19/08
Inventor M-C·塞甘
Owner EXSYMOL SA