LC-MC method used for determining NNK metabolites in liver microsomes
A technology of liver microsomes and liquid mass spectrometry, applied in the field of biochemical analysis, can solve the problems of limited application, low peak shape quality, radioactive contamination, etc., and achieve high detection sensitivity, simple pretreatment, and fast analysis speed Effect
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[0031] 1. Instruments and reagents:
[0032] Ultrapure water (resistivity ≥ 18.2 MΩ.cm); methanol (chromatographically pure, J&T Baker, USA); acetonitrile (chromatographically pure, J&T Baker, USA); formic acid (chromatographically pure, TEDIA, USA); ammonium formate (purity≥ 99%, Alfa Aesar Company); ammonium acetate (chromatographically pure, TEDIA Company, USA); 0.22 μm organic phase syringe filter (Agilent Company, USA).
[0033] 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); 4-(methylnitrosamino)-1-(3-pyridyl)-1- Butanol (NNAL); 4-(methylnitroso)-1-(3-pyridyl-N-oxide)-1-butanone (NNK-N-Oxide); 4-(methylnitroso) -1-(3-pyridyl-N-oxidation)-1-butanol (NNAL-N-Oxide); 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB); 1-( 3-pyridyl)-1,4-diol (PBD, hydroxy alcohol or diol); 1-(3-pyridyl)-1-butanone-4-carboxylic acid (keto acid); 1-(3- Pyridyl)-1-butanol-4-carboxylic acid (hydroxy acid, ammonium salt); 4-(methylnitrosamine)-1-(3-pyridyl-d 4 )-1-butanone (NNK-d 4 ); 4-Hydroxy-...
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