Vaginal ointment containing tioconazole and preparation method thereof

Abstract

The invention provides vaginal ointment containing tioconazole, and the vaginal ointment comprises the tioconazole, menthol crystal and pharmaceutical excipients, wherein the weight percentage of the tioconazole in the total weight of the ointment is between 5 percent and 8 percent, the weight percentage of the menthol crystal in the total weight of the ointment is between 1 percent and 6 percent, and the balance is the pharmaceutical excipients; and the tioconazole and the menthol crystal are distributed in the pharmaceutical excipients. A method for preparing the ointment comprises a process of distributing the tioconazole and the menthol crystal into the pharmaceutical excipients, wherein the process comprises the steps of smashing the tioconazole into powdery particles with the diameters between 10mu m and 50mu m, mixing the pharmaceutical excipients with the powdery particles of the tioconazole and the menthol crystal, and adding a preservative into the mixture and then stirring the mixture. The formula and the production technology of the tioconazole ointment provided by the invention are easy to implement, and by adding the menthol crystal to the formula, adverse reactions of local stimulation, pruritus, burning sensation, and the like, which occur in the use process of the existing tioconazole vaginal ointment preparation, are solved. The ointment provided by the invention can be used for treating vaginal fungus infection.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medicine, in particular to a vaginal ointment containing tioconazole and a preparation method thereof. Background technique [0002] Tioconazole is a new generation of imidazole antifungal drugs with strong efficacy and broad antibacterial spectrum. Its biggest feature is that it is difficult to absorb through the skin or mucous membranes. Therefore, it has almost no systemic effect when used as a local drug, thus avoiding some toxic and side effects. [0003] Tioconazole was first developed by Pfizer, which filed a patent application for tioconazole in the United States in 1975, with the patent number US4062966. And in 1985 applied for the patent of tioconazole composition, the patent number is US717423. The patent covers 100mg oral tablets, 1% and 2% creams, 6.5% ointment and 100mg vaginal tablets. This patent has now expired. [0004] Pfizer's topical tioconazole product was approve...

AI Technical Summary

Problems solved by technology

And menthol is added to the formula to solve the adverse reactions such as local irritation, itching and burning sensation during the use of the existing tioconazole vaginal ointment preparation