Suspension dispersible tablets and preparation method

A dispersible tablet and suspension technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of children's poor drug compliance, poor control of dosage, and inconvenient carrying, etc., to improve biological Utilization, convenient transportation and carrying, and good patient compliance

Active Publication Date: 2012-05-30
HAINAN PULIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The advantages of dry suspension are that the drug has a wide distribution area in the gastrointestinal tract, fast absorption, and high bioavailability, but it is inconvenient to carry and the dosage is not easy to control, especially for chil

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1: Preparation of 200 cefixime suspension and dispersible tablets

[0026] Prescription: Cefixime 28.2g sucrose 35g

[0027] Xanthan gum 2.01g Sodium carboxymethyl cellulose 0.5g

[0028] Microcrystalline cellulose 23.8g crospovidone 5.0g

[0029] Aspartame 2.0g Strawberry powder flavor 2.0g

[0030] Micro powder silica gel 0.5g Magnesium stearate 1.0g

[0031] Preparation:

[0032] (1). Sift the cefixime, sucrose, and sodium carboxymethyl cellulose to mix uniformly, then add purified water, granulate with a stirring granulator, dry the wet granules in an oven, and pass the dry granules through a 30-mesh sieve. Then add xanthan gum and mix evenly to obtain suspended particles;

[0033] (2) Mix the suspended particles with the remaining auxiliary materials in the prescription uniformly to obtain a mixed powder.

[0034] (3). Press the mixed powder into tablets to obtain.

[0035] The tablet weighs about 500 mg and its hardness is 25 Newtons. The hardne...

Example Embodiment

[0038] Example 2: Preparation of 1000 desloratadine suspension and dispersible tablets

[0039] prescription:

[0040] Deloratadine 7.9g Precipitated silica 0.1g

[0041] Eudragit E1002.5g Mannitol 87.5g

[0042] Lactose 87.5g Xanthan Gum 5.25g

[0043] Sodium carboxymethyl cellulose 3.5g microcrystalline cellulose 105g

[0044] Crospovidone 21g Aspartame 10.5g

[0045] Sweet orange flavor 12.25g micro powder silica gel 3.5g

[0046] Magnesium stearate 3.5g

[0047] Preparation:

[0048] (1) Firstly, desloratadine coated granules are prepared by desloratadine, precipitated silica and Eudragit E100;

[0049] (2). Sieve mannitol, lactose, and sodium carboxymethyl cellulose and mix evenly, then add purified water, in a stirring granulator, dry in a wet granulator oven, pass through a 30-mesh sieve, and then add xanthogen The glue is evenly mixed to obtain suspension particles;

[0050] (3) Mix the above-mentioned suspension granules with the remaining excipients in the prescription and the deslo...

Example Embodiment

[0052] Example 3: Preparation of 1000 azithromycin pellets capsules

[0053] Use the following prescription::

[0054] Azithromycin 100g Acrylic resin IV 35g

[0055] 150g mannitol 200g lactose

[0056] Xanthan gum 7.5g Sodium carboxymethyl cellulose 5g

[0057] Microcrystalline cellulose 150g crospovidone 30g

[0058] Aspartame 15g sweet orange flavor 17.5g

[0059] Micronized silica gel 5g Magnesium stearate 5g

[0060] Preparation Process:

[0061] (1) Coating azithromycin with acrylic resin IV to obtain azithromycin coated particles;

[0062] (2). Sieve mannitol, lactose and sodium carboxymethyl cellulose and mix evenly, then add purified water, granulate in a stirring granulator, dry in a wet granulator, pass through a 30-mesh sieve, and then add yellow The raw gum is mixed uniformly to obtain suspension particles;

[0063] (3) Mix the above-mentioned azithromycin-coated granules with the suspension granules and the remaining excipients in the prescription uniformly, and compress them w...

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Abstract

The invention relates to dosage forms of medicines, and discloses suspension dispersible tablets which at least comprise (1) an effective active component, (2) an excipient mixture at least comprising a disintegrating agent, and (3) suspension particles comprising a filling agent, a suspending agent and an adhesive. The suspension dispersible tablets have advantages as suspensions, such as wide distribution in gastrointestinal tracts and high bioavailability, and have advantages as tablets, such as appropriate hardness, easy transportation, easy carrying, and accurate dosage controlling.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a new dosage form suspension dispersible tablet and a preparation method thereof. Background technique [0002] According to the provisions of the Chinese Pharmacopoeia, dry suspensions are powders or granules made of insoluble solid drugs and suitable auxiliary materials, which can be dispersed into suspensions and taken orally by shaking before use. Dispersible tablets are tablets that disintegrate rapidly and disperse uniformly in water. Existing dispersible tablet is exactly to be made by compressing the tablet after mixing medicine and adjuvant at present, only meets the relevant quality standard of tablet. The quality of the suspension dispersible tablet prepared by the present invention, in addition to meeting the relevant requirements under the tablet item, also meets the relevant quality indicators of the Chinese Pharmacopoeia about dry suspensions, including ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/28A61K31/546A61K31/7052A61K31/4545A61K31/196
Inventor 范敏华徐海刘华周学来
Owner HAINAN PULIN PHARMA
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