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Peripheral static pressure measurement method based on micro-vesicle super-harmonic response

A super-harmonic and micro-bubble technology, applied in the direction of blood pressure measurement devices, etc., can solve problems such as increase, achieve low measurement threshold, high accuracy, and improve accuracy and reliability

Inactive Publication Date: 2012-06-13
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Peter J. A. Frinking (Trans. Ultrason. Ferroelectr. Freq. Control, 57, 1762-1771, 2010) found that Sono Vue produced A large increase (28.9 dB), which may be due to the nonlinear enhancement effect caused by the expansion and contraction of the microbubble envelope

Method used

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  • Peripheral static pressure measurement method based on micro-vesicle super-harmonic response
  • Peripheral static pressure measurement method based on micro-vesicle super-harmonic response
  • Peripheral static pressure measurement method based on micro-vesicle super-harmonic response

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] First, small test tubes, syringes, pressure gauges, and valves are bonded with silica gel to form a closed and controllable variable pressure system, and a moderate concentration (2-5×10 8 A / ml) microbubble solvent is placed in the test tube to be tested. The bottom of the test tube is immersed in the water tank for testing.

[0031] The signal generator (Agilent 33250, CA, USA) generates a 4MHz broadband pulse electrical signal (pulse length is 64 cycles), which is amplified by the power amplifier and transmitted to the transmitting transducer; the transmitting transducer converts it into an ultrasonic signal , and transmit to the microbubble sample, causing it to vibrate to generate a scattering signal; the receiving transducer (Panametrics, USA) is placed at a 90° angle with the transmitting transducer to ensure that the scattering signal is received and converted into an electrical signal for further Analysis; the signal received by the receiving transducer is amp...

Embodiment 2

[0034] Repeat the above process, change the pulse length to 20 cycles, and keep other settings unchanged, the result is as follows image 3 . The results show that the pulse length has an effect on the magnitude of the change of the superharmonic amplitude. The pulse is shortened, and the range of change becomes smaller, that is, the accuracy of measurement becomes smaller (because the amplitude becomes smaller and the slope of the curve becomes smaller, so the change of the ordinate corresponding to each abscissa unit becomes smaller).

Embodiment 3

[0036] Repeat the above process, change the pulse length to 128 cycles, and keep other settings unchanged, the result is as follows image 3 . The results show that the pulse length has an effect on the magnitude of the change of the superharmonic amplitude. The pulse is shortened and the range of change becomes larger, but the measurement accuracy does not always become larger. Because although the amplitude becomes larger, the curve no longer changes in a straight line, so the change of the ordinate corresponding to each abscissa unit is different, which is not conducive to measurement. In summary, the pulse length of 64 cycles is more suitable for measurement.

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Abstract

The invention provides a peripheral static pressure measurement method based on micro-vesicle super-harmonic response, which belongs to the expansion application field of ultrasound harmonic imaging technology and comprises the steps of arranging micro-vesicle solvents of contrast agents in peripheral static pressure environment to be tested, using a signal generator to generate an excitation signal, and magnifying the excitation signal through a power amplifier; using a transducer as a transmitting transducer, stimulating ultrasound harmonic signals in the micro-vesicle solvents under the action of the peripheral static pressure, and using another transducer as a receiving transducer to receive ultrasound scattered signals; then using fast fourier transform to treat the signals to obtain scattering atlas of the scattered signals and extract super-harmonic components in the frequency spectrograms; and calculating pulmonary artery blood pressure by comparing the change relation between super-harmonic component amplitude and peripheral pressure. The peripheral static pressure measurement method firstly uses the super-harmonic effect for measuring the pulmonary artery blood pressure and can effectively enhance measurement accuracy in the situation of certain excitation frequency and pulse signal periodicity compared with an existing sub-harmonic detection method.

Description

technical field [0001] The invention relates to a method for measuring peripheral static pressure, in particular to a method for measuring peripheral pressure by using microbubble superharmonic response. Background technique [0002] The measurement of pressure is of great significance in industries such as industry and medicine. Traditional pressure measurement methods are divided into liquid column type, elastic type, electric type and piston type according to different principles. The measured pressure is converted into liquid column height difference, elastic Component deformation displacement, electric quantity and weight of weight. These methods all require the direct receptor to be directly in the static pressure environment to be measured, so in some specific environments, traditional methods cannot be used to measure pressure, such as arterial blood pressure in the body, harsh environments that cannot be reached by instruments, etc. [0003] With the increasing dem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B8/04
Inventor 孙韬贾楠章东
Owner NANJING UNIV
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