Isoliquiritigenin eye drops and a preparation method thereof

A technology of isoliquiritigenin and eye drops, applied in the directions of pharmaceutical formulations, ketone active ingredients, sensory diseases, etc., to achieve the effects of inhibiting the occurrence and development process, significant curative effect, and simple preparation method

Inactive Publication Date: 2012-06-13
SHANDONG EYE INST
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Chinese medicine substances have extensive and effective biological activities, and the price is moderate. It is very necessary and important

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Isoliquiritigenin eye drops and a preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] The preparation method of the present invention is as follows:

[0022] Step 1. Preparation of isoliquiritigenin concentrate:

[0023] Weigh the dry isoliquiritigenin powder, add 10ml of ethanol to 1g of isoliquiritigenin dry powder, and use ethanol to fully dissolve it.

[0024] Step 2. Prepare phosphate buffer:

[0025] According to 6.0-10.0 parts of sodium chloride (NaCl), disodium hydrogen phosphate (NaH 2 PO 4 ·H 2 O) 1.0-2.0 parts, potassium chloride (KCl) 0.1-0.3 parts, potassium dihydrogen phosphate (KH 2 PO 4 ) 0.1-0.4 parts by weight to prepare phosphate buffer solution; and add 1-10 parts of thickener sodium carboxymethylcellulose. Adjust the pH value to 7.2-7.4. Sterilize at 120°C for 15 minutes, and let it cool for later use.

[0026] Step 3, use phosphate buffer to dilute the isoliquiritigenin concentrated solution to obtain the eye solution of the present invention:

[0027] The isoliquiritigenin eye drops of the present invention are obtained by ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Concentrationaaaaaaaaaa
Login to view more

Abstract

The invention relates to eye drops and a preparation method thereof and specifically provides isoliquiritigenin eye drops using isoliquiritigenin as a raw material and a preparation method thereof. The raw materials of the isoliquiritigenin eye drops have an optimum ratio as below: an isoliquiritigenin concentration of 40 mug / ml, a NaCl concentration of 8 mg / ml, a NaH2PO4.H2O concentration of1.44 mg / ml, a KCl concentration of 0.2 mg / ml, a KH2PO4 concentration of 0.24 mg / ml and a carboxymethylcellulose sodium concentration of 5 mg / ml. The eye drops of the present invention are prepared by a simple method and have substantial control effect on newborn blood vessel and wide application and developing prospect. Researches have proved that the eye drops prepared from isoliquiritigenin can effectively inhibit growth of newborn blood vessel of alkali burned mice, reduce infiltration of cornea inflammation cells and improve cornea oedema. Therefore, isoliquiritigenin has substantial curative effect on controlling cornea newborn blood vessel caused by cornea alkali burn and can effectively inhibit generation and development process of newborn eye blood vessel.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines for preventing and treating ocular neovascular diseases, and in particular relates to an isoliquiritigenin eye drop with isoliquiritigenin as a raw material and a preparation method thereof. Background technique [0002] Ocular neovascular disease has become the leading cause of blindness in my country, but its pathogenesis has not been fully understood, and there is a lack of effective treatment methods in clinical practice. At present, the commonly used methods for the treatment of neovascularization are laser photocoagulation and photocoagulation combined with photodynamic methods, but their long-term efficacy is not good and the cost is high. More importantly, once the neovascularization is formed, the damage and destruction to the eye will be irreversible. cause blindness in most patients. At present, drugs targeting ocular neovascularization are mainly vascular endothe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/12A61K9/08A61P27/02
Inventor 王宜强杨玲玲何文晓贾长凯王瑶宋子成
Owner SHANDONG EYE INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap