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Isoliquiritigenin eye drops and a preparation method thereof

A technology of isoliquiritigenin and eye drops, applied in the directions of pharmaceutical formulations, ketone active ingredients, sensory diseases, etc., to achieve the effects of inhibiting the occurrence and development process, significant curative effect, and simple preparation method

Inactive Publication Date: 2012-06-13
SHANDONG EYE INST
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Problems solved by technology

However, Chinese medicine substances have extensive and effective biological activities, and the price is moderate. It is very necessary and important to develop Chinese medicine active substances for the treatment and prevention of ocular neovascular diseases, but there is no effective medicine yet.

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  • Isoliquiritigenin eye drops and a preparation method thereof

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preparation example Construction

[0021] The preparation method of the present invention is as follows:

[0022] Step 1. Preparation of isoliquiritigenin concentrate:

[0023] Weigh the dry isoliquiritigenin powder, add 10ml of ethanol to 1g of isoliquiritigenin dry powder, and use ethanol to fully dissolve it.

[0024] Step 2. Prepare phosphate buffer:

[0025] According to 6.0-10.0 parts of sodium chloride (NaCl), disodium hydrogen phosphate (NaH 2 PO 4 ·H 2 O) 1.0-2.0 parts, potassium chloride (KCl) 0.1-0.3 parts, potassium dihydrogen phosphate (KH 2 PO 4 ) 0.1-0.4 parts by weight to prepare phosphate buffer solution; and add 1-10 parts of thickener sodium carboxymethylcellulose. Adjust the pH value to 7.2-7.4. Sterilize at 120°C for 15 minutes, and let it cool for later use.

[0026] Step 3, use phosphate buffer to dilute the isoliquiritigenin concentrated solution to obtain the eye solution of the present invention:

[0027] The isoliquiritigenin eye drops of the present invention are obtained by ...

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Abstract

The invention relates to eye drops and a preparation method thereof and specifically provides isoliquiritigenin eye drops using isoliquiritigenin as a raw material and a preparation method thereof. The raw materials of the isoliquiritigenin eye drops have an optimum ratio as below: an isoliquiritigenin concentration of 40 mug / ml, a NaCl concentration of 8 mg / ml, a NaH2PO4.H2O concentration of1.44 mg / ml, a KCl concentration of 0.2 mg / ml, a KH2PO4 concentration of 0.24 mg / ml and a carboxymethylcellulose sodium concentration of 5 mg / ml. The eye drops of the present invention are prepared by a simple method and have substantial control effect on newborn blood vessel and wide application and developing prospect. Researches have proved that the eye drops prepared from isoliquiritigenin can effectively inhibit growth of newborn blood vessel of alkali burned mice, reduce infiltration of cornea inflammation cells and improve cornea oedema. Therefore, isoliquiritigenin has substantial curative effect on controlling cornea newborn blood vessel caused by cornea alkali burn and can effectively inhibit generation and development process of newborn eye blood vessel.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines for preventing and treating ocular neovascular diseases, and in particular relates to an isoliquiritigenin eye drop with isoliquiritigenin as a raw material and a preparation method thereof. Background technique [0002] Ocular neovascular disease has become the leading cause of blindness in my country, but its pathogenesis has not been fully understood, and there is a lack of effective treatment methods in clinical practice. At present, the commonly used methods for the treatment of neovascularization are laser photocoagulation and photocoagulation combined with photodynamic methods, but their long-term efficacy is not good and the cost is high. More importantly, once the neovascularization is formed, the damage and destruction to the eye will be irreversible. cause blindness in most patients. At present, drugs targeting ocular neovascularization are mainly vascular endothe...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61K9/08A61P27/02
Inventor 王宜强杨玲玲何文晓贾长凯王瑶宋子成
Owner SHANDONG EYE INST
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