Preparation method of magnetic thermosensitive core-shell composite microsphere

A technology of composite microspheres and temperature-sensitive cores, which is applied in the direction of magnetism of organic materials/organic magnetic materials, can solve the problems of complicated operation in the preparation process of monodisperse magnetic temperature-sensitive composite microspheres, and achieve the effect of simple operation in the preparation process.

Inactive Publication Date: 2012-06-13
NORTHWESTERN POLYTECHNICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the disadvantages of complex operation in the preparation process of monodisperse magnetic temperature-sensitive composite microspheres prepared by existing methods, the present invention provides a method for preparing magnetic temperature-sensitive core-shell composite microspheres

Method used

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  • Preparation method of magnetic thermosensitive core-shell composite microsphere
  • Preparation method of magnetic thermosensitive core-shell composite microsphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: In the 50mL reactor that is equipped with condenser tube, add 30g distilled water, 1g methyl alcohol and 1g ethanol; With 0.005g Fe 3 o 4 Add the microspheres into a 50mL reactor and sonicate for 30min; add 0.003g of MBA (methylenebisacrylamide) and 0.03g of NIPAM (N-isopropylacrylamide) monomer mixture and 0.001g of KPS (potassium persulfate) Add to the reactor, shake to dissolve; pass N 2 After 25 minutes, gradually raise the temperature to 65°C, and polymerize for 10 hours; magnetically separate the obtained product, pour off the supernatant, add distilled water for ultrasonic dispersion, and then magnetically separate; repeat this process several times to remove excess monomer and polymerization thing. After vacuum drying at room temperature, the magnetic thermosensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 Microspheres.

[0018] After testing, the obtained magnetic temperature-sensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 The particle size of the mic...

Embodiment 2

[0019] Embodiment 2: In the 50mL reactor that is equipped with condenser tube, add 35g distilled water, 1g methyl alcohol and 2g ethanol; With 0.01g Fe 3 o 4 Add the microspheres into a 50mL reactor and sonicate for 25min; add 0.008g of MBA (methylenebisacrylamide) and 0.07g of NIPAM (N-isopropylacrylamide) monomer mixture and 0.0025g of APS (ammonium persulfate) Add to the reactor, shake to dissolve; pass N 2 After 28 minutes, gradually raise the temperature to 72°C, and polymerize for 7 hours; magnetically separate the obtained product, pour off the supernatant, add distilled water for ultrasonic dispersion, and then magnetically separate; repeat this process several times to remove excess monomer and polymerization thing. After vacuum drying at room temperature, the magnetic thermosensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 Microspheres.

[0020] After testing, the obtained magnetic temperature-sensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 The particle size of the micro...

Embodiment 3

[0021] Embodiment 3: in the 50mL reactor that is equipped with condenser tube, add 40g distilled water and 5g n-propanol; With 0.015g Fe 3 o 4 Add the microspheres into a 50mL reactor and sonicate for 25min; add 0.015g of MBA (methylenebisacrylamide) and 0.13g of NIPAM (N-isopropylacrylamide) monomer mixture and 0.001g of APS (ammonium persulfate) Add to the reactor, shake to dissolve; pass N 2 After 30 minutes, gradually raise the temperature to 70°C, and polymerize for 8 hours; conduct magnetic separation on the obtained product, pour off the supernatant liquid, add distilled water for ultrasonic dispersion, and then magnetically separate; repeat this process several times to remove excess monomer and polymerization thing. After vacuum drying at room temperature, the magnetic thermosensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 Microspheres.

[0022] After testing, the obtained magnetic temperature-sensitive core-shell P(NIPAM-MBA) / Fe 3 o 4 The particle size of the micro...

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Abstract

The invention discloses a preparation method of a magnetic thermosensitive core-shell composite microsphere to solve a technical problem of the complex operation of preparation processes of magnetic thermosensitive core-shell composite microspheres prepared through present methods. According to a technical scheme of the preparation method, the P(NIPAM-MBA) / Fe3O4 microsphere with the advantages of controllable particle size, monodispersity and high magnetic responsibility is prepared through a deposition polymerization process with monodisperse high-magnetic responsibility Fe3O4 needing no processing on the surface as the core, n-isopropyl acrylamide (NIPAM) as a functional monomer and methylene bisacrylamide (MBA) as a crosslinking agent. A process that a silane coupling agent is used to process the magnetic core to make the surface of the core have double bonds is omitted, so the preparation process is simple to operate.

Description

technical field [0001] The invention relates to a preparation method of composite microspheres, in particular to a preparation method of magnetic temperature-sensitive core-shell composite microspheres. Background technique [0002] Magnetic polymer composite microspheres refer to microspheres formed by combining magnetic inorganic particles and organic polymers by appropriate methods. Because it has both the magnetic responsiveness of magnetic substances and the multifunctionality of polymers (such as -COOH, -OH, -NH 2 , -SH, etc.), so it has broad application prospects in fields such as medicine, molecular biology, and biochemistry. [0003] The preparation of polymer magnetic temperature-sensitive composite microspheres has attracted more and more attention from researchers at home and abroad. The document "Chinese Patent Publication No. CN100575376C" discloses a biocompatible magnetic temperature-sensitive nanoparticle and a preparation method thereof. [0004] The do...

Claims

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Application Information

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IPC IPC(8): C08F220/54C08F222/38C08F2/44C08K3/22H01F1/42
Inventor 张秋禹马明亮张和鹏尹德忠窦金波赵兴波陈少杰
Owner NORTHWESTERN POLYTECHNICAL UNIV
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