Method and device for measuring optical parameter of chaotic medium by multi-wavelength space resolution phase lock

Abstract

The invention belongs to the field of measurement of optical parameters in organization optical research, and relates to a device for measuring an optical parameter of a chaotic medium by multi-wavelength space resolution phase lock. The device comprises a light source part, a detection part, a data acquisition part and a computer, wherein the light source part comprises a plurality of different lasers with near infrared wavelengths, a multi-channel direct digital synthesized sine signal modulator and a single-mode optical fiber; the detection part comprises a source optical fiber bundle, a fixing frame for the source optical fiber bundle, a detection optical fiber, a fixing frame for the detection optical fiber, an electric translation platform and a silicon photoelectric diode detector; the fixing frame for the detection optical fiber is arranged on the electric translation platform, so that the detection optical fiber is moved by the electric translation platform; a diffuse reflection mixed optical signal acquired by the detection optical fiber is converted into an electric signal by the silicon photoelectric diode detector; and the computer is used for performing digital phase lock and curve fitting on a digital signal input by the data acquisition part, and reconstructing the optical parameter. According to the device, quick and woundless in-vitro or in-vivo measurement of an organizer under different wavelengths is realized.

Description

[0001] method field [0002] The invention belongs to the field of optical parameter measurement in tissue optics research, in particular to a multi-wavelength spatial resolution phase-locked measurement method and device for optical parameters of chaotic media. technical background [0003] Since most of the human tissue is water, and water has low absorption in the 600-900nm (usually called the 'near-infrared light measurement and treatment window') [1] band, most of the soft tissue in this band is an optical chaotic medium, presenting Low absorption and high scattering characteristics, so the emitted light of the tissue in this band is mainly diffuse light, which carries rich physiological and pathological information of the tissue, so the optical parameters based on the multi-wavelength diffuse light in the near infrared band (absorption coefficient and reduced scattering coefficient) measurement can obtain more accurate physiological and pathological information of the ti...

AI Technical Summary

Problems solved by technology

[0005] Although the time-domain (TD) measurement method has the advantages of relatively complete measurement information and only single-point measurement, its measurement system is expensive and difficult to popularize in small laboratories

[0006] The frequency domain (FD) measurement method generally requires high-frequency modulation above 200MHz to achieve a reasonable signal-to-noise ratio required for phase shift measurement, which is difficult to achieve. The measurement is not dominant and cannot provide more functional information of the organoid

[0007] The multi-wavelength spatially resolved optical parameter measurement method based on continuous light has become one of the important research contents of emerging biomedical photonics. At present, foreign scientists have done a lot of work in this area and achieved many results. There are few studies in this area. This technique utilizes the “window effect” of tissue and the spatially resolved phase-locked measurement of continuous light to provide rich information on the diffuse reflection of photons in chaotic tissues, which can effectively detect the optical parameters of different organs (absorption and Scattering coefficient), as a light detection and diagnosis technology, this method has broad application prospects in important fields such as optical positioning and imaging of brain function, real-time monitoring of neonatal brain development, etc.

Images