PRocess for production of L-amino acid

Abstract

A process for producing an L-amino acid, comprising culturing a coryneform bacterium that is capable of producing the L-amino acid and has been so modified as to have an enhanced carbonic anhydorase activity in a culture medium to produce and accumulate the L-amino acid in the culture medium or cells of the bacterium and collecting the L-amino acid from the culture medium or the cells.

Description

technical field [0001] The present invention relates to the efficient production of L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-asparagine, L-aspartic acid, L - The method of lysine, L-methionine, L-threonine and L-isoleucine. Background technique [0002] L-amino acid is produced mainly by using L-amino acid producing bacteria called coryneform bacteria belonging to the genus Brevibacterium, Corynebacterium or Microbacterium, or mutant strains thereof. Industrial production by fermentation (see, for example, Non-Patent Document 1). As a method for producing L-amino acid by fermentation using other bacterial strains, the following method is known: a method using microorganisms belonging to the genus Bacillus, Streptomyces, or Penicillium, etc. (See, for example, Patent Document 1), a method using microorganisms belonging to the genus Pseudomonas, Arthrobacter, Serratia, or Candida (see, for example, Patent Document 2), a method using micro...

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Problems solved by technology

In addition, it has been reported that in the study of enhancing β carbonic anhydrase of bacteria of the genus Corynebacterium, the production amount of lysine was not increased (see Non-Patent Document 4), and it is still unknown whether the enhancement of β carbonic anhydrase has an effect on the substance production Effective, and the relationship between β-carbonic anhydrase activity and L-amino acid productivity

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