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Mangiferin cream with anti-herpes virus effect

A glycoside cream and mangiferin technology, which is applied in the field of mangiferin cream preparations, can solve the problems of no mangiferin cream, low bioavailability, and no mangiferin cream patents.

Inactive Publication Date: 2013-01-09
广西中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) The bioavailability in the intestinal tract of mice is low, and the blood concentration is very low (measured value<5μg·mL-1)
[0006] After searching, in the existing periodical documents related to mangiferin, there is no report about mangiferin cream and its use; in the published patent literature, no mangiferin cream and its manufacturing process have been found. Patents related to use

Method used

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  • Mangiferin cream with anti-herpes virus effect
  • Mangiferin cream with anti-herpes virus effect
  • Mangiferin cream with anti-herpes virus effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: Mangiferin micronization treatment

[0028] Take mangiferin (purity > 98%), mix well with sodium lauryl sulfate and crospovidone (mass ratio is 50:1:1), and carry out ball milling (the ball mill uses a stainless steel tank with built-in agate balls) at a speed of 400 per minute, pulverized for 45 minutes, and then taken out through a 200-mesh sieve for later use to obtain micronized mangiferin.

Embodiment 2

[0029] Embodiment 2: the preparation of mangiferin cream (2.5%)

[0030] prescription:

[0031] Mangiferin 25g

[0032] Base 975g

[0033] Its matrix prescription is as follows:

[0034]

[0035] Preparation method: Take 100g of stearic acid and 25g of glyceryl monostearate, and heat to 80±2°C to prepare oil phase A. Then take 0.5g of triethanolamine, 100g of glycerin, 1g of ethylparaben, add an appropriate amount of water (the total amount of water added should make the total weight of the oil phase and the water phase is 1000g), dissolve in it, and heat it to 85±2°C to obtain the water phase B. Add the water phase B into the oil phase A, stir while adding, the stirring speed is 150 rpm, make it into a uniform paste, cool to 50±5°C under stirring, and get the blank matrix. Take an appropriate amount of mangiferin micropowder (equivalent to 25g of pure mangiferin), 975g of cream base, put it in a colloid mill, mix it with the base evenly, cool to room temperature, and p...

Embodiment 3

[0036] Embodiment 3: the preparation of mangiferin cream (5%)

[0037] prescription:

[0038] Mangiferin 50g

[0039] Base 950g

[0040] Its matrix prescription is as follows:

[0041]

[0042]

[0043] Preparation method: take 85g of stearic acid and 35g of glyceryl monostearate, and heat to 90±2°C to prepare oil phase A. Then take 0.5g of triethanolamine, 80g of glycerin, and 1g of ethylparaben, add appropriate amount of water (the total amount of water added should make the total weight of the oil phase and the water phase is 1000g) to dissolve, and heat to 92±2°C to obtain the water phase B. Add the water phase B into the oil phase A, stir while adding, the stirring speed is 100 rpm, make it into a uniform paste, cool to 40±5°C under stirring, and get the blank matrix. Take an appropriate amount of mangiferin micropowder (equivalent to containing 50g of pure mangiferin), 950g of cream base, put it in a colloid mill, mix with the base evenly, cool to room temperat...

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PUM

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Abstract

The invention discloses an external cream preparation for effectively treating herpes simplex virus (HSV) I type and II type infectious diseases and a preparation method as well as application thereof. The cream is prepared from high-purity mangiferin (purity of greater than or equal to 90 percent) serving as a raw material and proper auxiliary materials, wherein the mangiferin raw material is treated by using a micronization technique. Experiments prove that the cream has a good anti-herpes simplex virus effect, fast response and obviously shortened recovery time after the mangiferin raw material is micronized. The preparation method for the mangiferin cream is simple and convenient, and can be easily promoted to industrial large-scale production. Anti-herpes simplex virus pharmaceuticaleffect evaluation experiments and clinical pretests prove that the mangiferin cream has good curative effect on treatment of HSV-1 and HSV-2 infection, high safety and no toxic and side effects.

Description

technical field [0001] The invention relates to a mangiferin cream preparation with anti-type 1 and type 2 herpes virus effects. Background technique [0002] Sexually transmitted diseases are a class of diseases that are very popular in the world and are very harmful. In my country, the number of sexually transmitted diseases is increasing at a rate of 15% every year. In 2002, more than 700,000 cases of 7 kinds of sexually transmitted diseases (except HIV / AIDS) were reported in 31 provincial-level administrative regions of my country. The situation is very serious. STD patients and their pathogen carriers are the main source of infection of sexually transmitted diseases. The population is generally susceptible to sexually transmitted diseases, with almost no age and gender differences. Moreover, the population has neither innate immunity nor stable immunity to sexually transmitted diseases. Acquired immunity, can be re-infected, long-term cure. [0003] Herpes simplex vir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/352A61K47/18A61P31/22
Inventor 邓家刚吴玉强梁健钦郝二伟侯小涛杜正彩李学坚
Owner 广西中医学院