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Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins

A technology of Panax notoginseng saponins and a purification method, which is applied in the field of traditional Chinese medicine chemistry and achieves the effects of low price, few organic residues and convenient use.

Active Publication Date: 2012-07-04
北京中海康医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to provide a purification method for preparing more efficient and higher-purity Panax notoginseng total saponins, while solving the deficiencies and defects of the existing production technology

Method used

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  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins
  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins
  • Method for purifying panax notoginseng total saponins and preparation of panax notoginseng total saponins

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Effect test

preparation Embodiment 1

[0026] Get dry Radix Notoginseng main root 20.0kg, pulverize with Chinese herbal medicine grinder (purchased from Tianjin Tester Instrument Co., Ltd.), pass No. 3 sieve, be 60% ethanol solution 55 ℃ decompression reflux extraction with the concentration of 12 times of medical material weight Each time, 2.0 hours each time, combine the extracts, recover the ethanol to the end, add 1 volume of purified water to the concentrate, stir evenly, and place it in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, adsorb on HPD-700 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) on the filtrate, first elute with deionized water, use molish reaction and thin layer chromatography to control the elution end point, discard the elution solution, and then eluted with 12 times column volume of 70% ethanol solution, collected the eluate, concentrated under reduced pressure at low temperature to 0.2g medicinal material / ml, then added to polyami...

preparation Embodiment 2

[0028] Get dry Radix Notoginseng main root 20.0kg, pulverize with Chinese herbal medicine pulverizer (purchased from Tianjin Tester Instrument Co., Ltd.), pass No. 3 sieve, be 60% ethanol solution 50 ℃ decompression reflux extraction 2 with the concentration of 12 times of medical material weight Each time, 2.0 hours each time, combine the extracts, recover the ethanol to the end, add 1 volume of purified water to the concentrate, stir evenly, and place it in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, adsorb on HPD-400 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) on the filtrate, first elute with deionized water, use molish reaction and thin layer chromatography to control the elution end point, discard the elution solution, and then eluted with 12 times column volume of 70% ethanol solution, collected the eluate, concentrated under reduced pressure at low temperature to 0.2g medicinal material / ml, then added to po...

preparation Embodiment 3

[0030] Get 20.0kg of dried Panax notoginseng main root, use a Chinese herbal medicine pulverizer (purchased from Tianjin Tester Instrument Co., Ltd.) to pulverize, pass through a No. 3 sieve, and use a concentration of 10 times the weight of the medicinal material to extract 10% ethanol solution under reduced pressure at 55°C. Each time, 3.0 hours each time, combine the extracts, recover ethanol to the end, add 1 times the volume of purified water to the concentrate, stir evenly, and place it in the refrigerator for 24 hours. Take out the refrigerated liquid, filter, and adsorb on AB-8 resin (purchased from Cangzhou Baoen Adsorption Material Technology Co., Ltd.) on the filtrate, first elute with deionized water, use molish reaction and thin layer chromatography to control the end point of elution, discard the elution solution, then elute with 10 times column volume of 80% ethanol solution, collect the eluate, concentrate under reduced pressure at low temperature to 0.2g medici...

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Abstract

The invention relates to a method for purifying panax notoginseng total saponins and a preparation of the panax notoginseng total saponins, and aims to provide a purifying method capable of preparing panax notoginseng total saponins with higher efficiency and higher purity and overcoming the defects of the prior art. The purifying method breaks through the conventional method for purifying the panax notoginseng total saponins; impurity removal, decolorization and enrichment of the total saponins can be effectively implemented by fully combining different purifying effects of macroporous resin, polyamide and active carbon; and the polyamide is filtered by one step of washing operation, so the process is simple, an organic solvent is saved and industrialized production is easily realized. The invention also comprises the medicinal preparation of the panax notoginseng total saponins, and the preparation can be prepared into power injection, injection, tablets or capsules.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine chemistry, and in particular relates to a purification method of Panax notoginseng saponins and a preparation thereof. Background technique [0002] Panax notoginseng is the dry root and rhizome of Panax notoginseng (Burk.) F.H.Chen. It is warm in nature, sweet in taste, slightly bitter, and enters the stomach meridian. Function cures mainly for removing blood stasis and stopping bleeding, reducing swelling and relieving pain. For hemoptysis, hematemesis, hematochezia, uterine bleeding, traumatic bleeding, chest and abdomen tingling pain, tumbling and swelling pain. Mainly produced in Yunnan Wenshan, Yanshan, Guangnan, Maguan and Guangxi Jingxi, Mubian, Baise and other places. [0003] Panax notoginseng contains a variety of ingredients, among which total saponins of notoginseng are the main active ingredients of notoginseng, which are mainly distributed in the roots and rhizomes of ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/06A61P3/10A61P7/02A61P9/10A61P37/02
Inventor 孙武兴李青原黄海秦玉霞
Owner 北京中海康医药科技发展有限公司
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