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In-vivo degradable polymer tubular material for subcutaneous implantation of capsules and preparation method thereof

A polymer and polymer solution technology, applied in medical science, surgery, etc., can solve the problems of patients' pain and increase the cost of surgery, and achieve the effects of avoiding pain, excellent processability, and avoiding inflammatory reactions

Active Publication Date: 2013-07-03
JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the high polymer tubular material used for subcutaneously implanted capsules, such as the drug carrier disclosed in the patent documents CN 2712349 Y and CN201150664 Y, is a non-degradable medical silicone rubber. Removal by one operation increases the cost of the operation and causes further pain to the patient

Method used

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  • In-vivo degradable polymer tubular material for subcutaneous implantation of capsules and preparation method thereof
  • In-vivo degradable polymer tubular material for subcutaneous implantation of capsules and preparation method thereof

Examples

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specific Embodiment approach 1

[0029] Embodiment 1: Dissolve 0.90g PLGA (PL: GA 85 / 15 Mw: 65000) and 0.10g PEG (Mw: 6000) into 10ml of dichloromethane, stir to form a uniform polymer solution, and let it stand for defoaming , set aside; in the obtained homogeneous solution, adopt the pulling method to form a polymer tube film on the surface of the columnar mold, dry at room temperature for 1 hour, pull and shape again, repeat 5 times, and reach the desired thickness, and finally vacuum dry at 40°C for 24 hours to remove Organic solvent; the obtained product is soaked in deionized water for 24 hours, and demolded to obtain a polymer tubular product with an inner diameter of 3mm and a wall thickness of about 0.02mm. The surface appearance of the obtained tubular material is as follows: figure 1 As shown, the in vitro degradation mass change curve is shown as figure 2 -A shown.

specific Embodiment approach 2

[0030] Specific embodiment two: Dissolve 0.95g PLGA (PL: GA 85 / 15 Mw: 65000) and 0.05g PEG (Mw: 6000) in 10ml of dichloromethane, stir to form a homogeneous polymer solution, and stand for defoaming , set aside; in the obtained homogeneous solution, adopt the pulling method to form a polymer tube film on the surface of the columnar mold, dry at room temperature for 1 hour, pull and shape again, repeat 5 times, and reach the desired thickness, and finally vacuum dry at 40°C for 24 hours to remove Organic solvent; the obtained product is soaked in deionized water for 24 hours, and demolded to obtain a polymer tubular product with an inner diameter of 3 mm and a wall thickness of about 0.02 mm. The in vitro degradation quality change curve of the obtained tubular material is as follows: figure 2 -B is shown.

specific Embodiment approach 3

[0031] Specific embodiment three: Dissolve 0.90g PLGA (PL: GA 75 / 25 Mw: 100000) and 0.10g PEG (Mw: 6000) in 10ml of dichloromethane, stir to form a uniform polymer solution, and let it stand for defoaming , set aside; in the obtained homogeneous solution, use the pulling method to form a polymer tube film on the surface of the columnar mold, dry at room temperature for 1 hour, pull and shape again, repeat 5 times, to reach the expected thickness, and finally vacuum dry at 40°C for 24 hours to remove Organic solvent; the obtained product is soaked in deionized water for 24 hours, and demolded to obtain a polymer tubular product with an inner diameter of 3 mm and a wall thickness of about 0.02 mm. The in vitro degradation quality change curve of the obtained tubular material is as follows: figure 2 -C curve shown.

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Abstract

The invention provides an in-vivo degradable polymer tubular material for subcutaneous implantation of capsules and a preparation method of the material. The preparation method comprises the steps of: (1) uniformly dispersing degradable polymer blend in organic solvent to form a polymer solution, stirring to be uniform, standing and debubbling; (2) forming polymer tubular film on a cylindrical mold surface from the polymer solution obtained in the step (1) by a pulling method, drying at room temperature for 1h to finish one pulling and molding cycle, repeating the pulling and molding cycle toachieve an expected thickness, and finally vacuum-drying at 40 DEG C for 24h to remove organic solvent and obtain a product; and (3) immersing the product obtained in the step (2) in deionized water for 3h, taking out, soaking in a solution formed from deionized water and absolute ethanol at a volume ratio of 1:1 for 1h, taking out, drying, then immersing in deionized water for 3h, and demolding to obtain the polymer tubular material. According to the invention, the used material is the degradable polymer with excellent biological compatibility; the inside diameter of the obtained tubular material is determined by the diameter of the cylindrical mold; and the obtained tubular material is suitable for subcutaneous implantation of controlled release substances.

Description

technical field [0001] The invention relates to a biomedical material, in particular to an in vivo degradable polymer tubular material used for subcutaneously implanted capsules. Background technique [0002] With the continuous development of material science and medicine, non-degradable polymer materials are gradually replaced by degradable polymer materials in the application field of biomedical materials. After the non-degradable polymer material is implanted in the body, it will exist permanently, and there is a hidden danger of causing inflammation. Therefore, people are constantly researching and developing degradable polymer materials, so that they can be gradually degraded, absorbed and excreted with the regeneration of organs or tissues, so as to minimize the adverse effects on the body. Because biodegradable materials are easy to decompose in vivo, and their decomposition products can be metabolized and finally excreted from the body, they have attracted more and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08L71/02A61L31/06
Inventor 李莉李珍刘西伟候理达李新林郑玉峰
Owner JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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