Unlock instant, AI-driven research and patent intelligence for your innovation.

Pharmaceutical composition containing orlistat and its preparation method

A technology of orlistat and composition, applied in the field of composition containing orlistat and its preparation

Active Publication Date: 2013-08-07
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the technical defects of problems such as sticking, bonding and re-aggregation, complicated process and low dissolution rate in the existing process, and provide a An oral preparation with stable preparation properties, and a simple and efficient process for preparing the preparation with stable properties, which is suitable for large-scale industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing orlistat and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 (comparative example, the technical solution of the present invention is not adopted)

[0033] Orlistat 120g

[0034] Microcrystalline cellulose 60g

[0035] Sodium starch glycolate 15g

[0036] Silica 3g

[0037] Magnesium stearate 1g

[0038] 1000 capsules

[0039] Preparation Process:

[0040] 1. Weigh the prescription amount of orlistat, silicon dioxide, sodium starch glycolate, microcrystalline cellulose and magnesium stearate, and mix them evenly;

[0041] 2. Fill the capsule and get it.

Embodiment 2

[0043] Orlistat 30g

[0044] Microcrystalline cellulose 105g

[0045] Sodium starch glycolate 15g

[0046] Silica 3g

[0047] Magnesium stearate 1g

[0048] 1000 capsules

[0049] Preparation Process:

[0050] 1. Weigh the prescription amount of orlistat and sodium starch glycolate, grind and mix in a grinding mixer at a low temperature of -30°C to obtain mixed particles;

[0051] 2. Weigh the other excipients in the prescription amount and the above-mentioned mixed particles, and mix them evenly;

[0052] 3. Fill the capsule and get it.

Embodiment 3

[0054] Orlistat 30g

[0055] Microcrystalline cellulose 112g

[0056] Sodium starch glycolate 5g

[0057] Silica 5g

[0058] Magnesium stearate 1.5g

[0059] 1000 capsules

[0060] Preparation Process:

[0061] 1. Weigh the prescription amount of orlistat, sodium starch glycolate and silicon dioxide, grind and mix in a grinding mixer at a low temperature of -15°C to obtain mixed particles;

[0062] 2. Weigh the other excipients in the prescription amount and the above-mentioned mixed particles, and mix them evenly;

[0063] 3. Press the tablet and get it.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a pharmaceutical composition containing orlistat. The pharmaceutical composition comprises on a weight basis: 1 portion of orlistat, 0.04-0.05 parts of hydrophilic accessories; the orlistat and the hydrophilic accessories are grinded and mixed in a low temperature of -45 to -15 DEG C to get mixed granules, then mixed with pharmaceutically acceptable 0-100 parts of accessories to make capsules, tablets or granules. The orlistat composition of the invention does not contain surfactants; the method solves adhesion, bonding phenomena and defects of low dissolution by mixing and grinding orlistat and hydrophilic accessories in a low temperature. The method of the invention guarantees better dissolution of orlistat, improves product quality, provides simple production process and can be industrially produced.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a composition containing orlistat and a preparation method thereof. Background technique [0002] Obesity has become a global epidemic. The main cause of obesity is that the body's energy intake exceeds consumption, and the excess energy is stored in the form of fat. The energy balance of the body is affected by multiple factors such as diet, exercise, endocrine diseases and genetics. A combination of energy restriction and increased exercise is recommended as an effective weight loss strategy. Even so, with the forward development of the domestic economy and the continuous improvement of people's living standards, obese patients will continue to increase, and the number of obese patients in different ages, regions, occupations and other groups will increase, so the demand for weight loss drugs will still increase significantly . [0003] Orlistat was deve...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K9/20A61K9/48A61K31/365A61P3/04A61P3/06
Inventor 庞丹梅潘福生
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST