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Medicine-loaded coating and preparation method thereof

A drug-loaded coating and drug-loaded technology, applied in coatings, medical science, surgery, etc., can solve problems such as volatile, environmental pollution, composition changes, etc., to extend the cycle, avoid environmental pollution, and facilitate addition and adjustment Effect

Inactive Publication Date: 2012-07-11
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because organic solvents are easy to volatilize, it is easy to cause changes in the composition of organic solvent solutions of degradable polymer materials and drugs, which affects the quality of drug-loaded coatings; in addition, organic solvents are also easy to cause environmental pollution

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The inner diameter of 0.2mm lactide and glycolide copolyester fiber cross braided is 6mm, the length is 45mm, on the tubular thing with network structure, coat chitosan-acetic acid-water solution (chitosan The mass concentration is 2%, the mass ratio of acetic acid to water is: 3: 100), the coating amount is 0.08 g, and then the tube-shaped thing coated with chitosan acetic acid-water solution is placed in 20 ℃ of absolute ethanol, after shaking for 10 minutes Take it out; then place it in fresh 20°C absolute ethanol, shake it for 10 minutes and take it out to completely elute the acetic acid; then dry it in a vacuum oven at 35°C for 30 minutes to remove the ethanol, and then get the chitosan-coated lactate Ester and glycolide copolyester fibrous scaffold, the amount of chitosan is 1.6mg.

[0038] Coat the azithromycin-polycaprolactone nano-submicron particle aqueous dispersion on the above-mentioned lactide and glycolide copolyester fiber support with chitosan coating ...

Embodiment 2

[0040] On the lactide and glycolide copolyester fiber scaffold with chitosan coating and polycaprolactone nanocoating loaded with azithromycin obtained in Example 1, paclitaxel-polycaprolactone nano- Submicron particle water dispersion (paclitaxel content is 0.60mg / g, polycaprolactone content is 3.00mg / g), the coating amount is 0.095g, and then dried in a vacuum oven at 40°C for 40 minutes to remove moisture, and the surface of the stent Paclitaxel 0.057mg and polycaprolactone 0.29mg were added in the coating, and in the polycaprolactone coating loaded with azithromycin and paclitaxel finally formed, the amount of azithromycin was 0.23mg, the amount of paclitaxel was 0.057mg, and the polycaprolactone The amount is 0.67mg.

Embodiment 3

[0042] On the lactide and glycolide copolyester fiber scaffold with chitosan coating and polycaprolactone nanocoating loaded with azithromycin obtained in Example 1, coat azithromycin-polycaprolactone nano- Submicron particle aqueous dispersion (azithromycin content is 2.15mg / g, polycaprolactone content is 3.58mg / g), coating amount is 0.098g, and then dried in a vacuum oven at 60°C for 20 minutes to remove moisture, and the surface of the stent 0.21 mg of azithromycin and 0.35 mg of polycaprolactone were added to the coating, and in the finally formed polycaprolactone coating loaded with azithromycin, the amount of azithromycin was 0.44 mg, and the amount of polycaprolactone was 0.73 mg.

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Abstract

The invention relates to a medicine-loaded coating and a preparation method thereof, in particular to a coating for a thermoplastic degradable fibrous woven stent and a preparation method for the coating. The medicine-loaded coating is a medicine-loaded thin layer which is formed on a plurality of pores and a relatively rough chitosan thin-film layer of the surface of a stent. The method for preparing the degradable medicine-loaded coating comprises the following steps of: (1) coating a chitosan-acetic acid-aqueous solution on the surface of the degradable fibrous woven stent, putting into absolute ethanol, and removing ethanol to form a chitosan coating; (2) coating a medicine-loaded polycaprolactone water dispersion on the chitosan coating, and removing the moisture to form a medicine-loaded polycaprolactone coating; and (3) continuing to coat the medicine-loaded polycaprolactone water dispersion, and adding and adjusting the medicine loading capacity and medicine loading variety. The invention is characterized in that: the method is simple and convenient; and the medicine loading variety, coating thickness and medicine loading capacity are convenient to regulate and control.

Description

technical field [0001] The invention relates to a drug-loaded coating and a preparation method thereof, in particular to a coating of a thermoplastic degradable fiber braided stent and a preparation method thereof, in particular to a drug-loaded thin layer formed on the surface of the porous and surface of the stent Drug-loaded coatings on rougher chitosan thin film layers and methods for their preparation. Background technique [0002] A stent is a device used to support the internal pipes of the human body, and has the function of preventing these pipes from being blocked or narrowed. The surface of the stent is often coated with drugs to prevent the growth and aggregation of human tissue or the reproduction of bacteria on the surface of the stent, so as to ensure the smoothness of the human pipeline. The method currently used to prepare drug-loaded coatings for stents is to dissolve degradable polymer materials and drugs in organic solvents to form an organic solvent sol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/16A61L31/10A61L31/06
Inventor 赵炯心张幼维张秀芳陈南梁徐敏李文刚
Owner DONGHUA UNIV
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