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Stress-alleviating agent comprising plant-derived polyamine-containing extract as active ingredient

A plant-derived, amine extract technology, applied in the direction of organic active ingredients, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc., can solve the problem of unknown anti-stress effects or stress relief of polyamines effect and other problems, to achieve the effect of excellent stress reducing effect

Active Publication Date: 2012-07-11
TOYOBO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not at all known whether polyamines provide an anti-stress effect or a stress-reducing effect specifically on skin cells (fibroblasts)

Method used

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  • Stress-alleviating agent comprising plant-derived polyamine-containing extract as active ingredient
  • Stress-alleviating agent comprising plant-derived polyamine-containing extract as active ingredient
  • Stress-alleviating agent comprising plant-derived polyamine-containing extract as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0101] (Example 1A: Preparation of soybean-derived polyamine-containing extract)

[0102] Diluted internal standard solution (1,7-diaminoheptane; internal standard amount = 1200 nmol) and 500 mL of 5% perchloric acid aqueous solution were added to 100 g of soybean germ (manufactured by FOR YOU corporation) and left to stand at room temperature for 1 hour . The resulting solution was then mixed with 16 g of Polyclar VT (manufactured by ISP Inc.) as a polyphenol adsorbent. Soybean germ was thoroughly pulverized with a blender mixer, and then extracted under acidic conditions by standing at room temperature for 30 minutes. The pulverized material was subjected to centrifugation at 2°C and 22,000 xg for 20 minutes, and the liquid fraction was collected. The liquid fraction was neutralized with 30% sodium hydroxide solution. The resulting solution was defined as plant extract (soybean germ extract; LGS). The plant extract contained in total 57.1 mg of polyamines: 23.5 mg of put...

Embodiment 1B

[0103] (Example 1B: Preparation of soybean-derived polyamine-containing extract)

[0104] Soybean germ samples (1 kg each, soybean germ powder manufactured by FOR YOU corporation) were mixed with 0.1N, 0.5N and 1N hydrochloric acid solutions (6 L each). Each of the resulting solutions was then mixed with 80 g of Divergan F (manufactured by BASF) serving as a polyphenol adsorbent and extracted under acidic conditions by stirring at room temperature for 2 hours with a Three-one Motor. The stirred material was centrifuged at 4°C and 12,000 xg for 30 minutes and the liquid fraction was collected. The liquid fraction was neutralized with 30% sodium hydroxide solution. The resulting solution was then subjected to centrifugation at 4° C. and 12,000×g for 30 minutes and the liquid fraction was collected. This solution was defined as plant extract (soybean germ extract; LGS).

[0105] The plant extract according to 0.1 N hydrochloric acid contained in total 416.1 mg of polyamines: 2...

Embodiment 1C

[0107] (Example 1C: Preparation of soybean-derived polyamine-containing extract)

[0108] Soybean germ samples (1 kg each, soybean germ powder manufactured by FOR YOU corporation) were mixed with 0.1N, 0.5N and 1N sulfuric acid solutions (6 L each). Each of the resulting solutions was then mixed with 80 g of Divergan F (manufactured by BASF) serving as a polyphenol adsorbent and extracted under acidic conditions by stirring at room temperature for 2 hours with a Three-one Motor. The stirred material was centrifuged at 4°C and 12,000 xg for 30 minutes and the liquid fraction was collected. The liquid fraction was neutralized with 30% sodium hydroxide solution. The resulting solution was then subjected to centrifugation at 4° C. and 12,000×g for 30 minutes and the liquid fraction was collected. This solution was defined as plant extract (soybean germ extract; LGS).

[0109] The plant extract according to 0.1 N sulfuric acid contained in total 421.6 mg of polyamines: 220.8 mg ...

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Abstract

Disclosed is a composition for preventing or inhibiting stress at the cellular level, which contains a plant-derived polyamine-containing extract and has a stress-alleviating activity, an anti-stress activity, a stress-reducing activity, a stress-preventing activity, a stress-inhibiting activity, a stress-protecting activity and the like. Also disclosed is a cosmetic, a quasi drug, a medical supply, a hygiene product, a medicine, a food or a beverage which comprises the composition. Specifically disclosed is a stress-alleviating agent, which is characterized by comprising a plant-derived polyamine-containing extract as an active ingredient

Description

technical field [0001] The present invention relates to substances that enhance stress-relieving effects in various cells and uses of such substances. Background technique [0002] Humans and animals are affected by various stresses. Such stress strongly involves environmental factors. Environmental factors may be natural factors such as ambient temperature (temperature), humidity (dryness) or ultraviolet light; as well as factors related to nutrition, living environment or lifestyle. Humans and animals are often subject to stress due to natural factors, and various resulting diseases and the like strongly involve a decrease in cell division speed or a decrease in cell function. For example, skin is composed of epidermal cells, fibroblasts, and an extracellular matrix, such as elastin or collagen, that supports the skin structure on the outside of the epidermal cells and fibroblasts. In young skin, the interaction between skin tissues remains constant, and as a result, mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/131A61K31/132A61K36/00A61P17/16A61P25/20A61P43/00
CPCA61K36/48A61K31/132A61K8/97A61Q19/08A61K8/9789A61K8/9794A61P17/16A61P25/20A61P25/22A61P43/00
Inventor 北泽宏明春日部芳久北川优
Owner TOYOBO CO LTD
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