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Composite membrane for promoting wound repair by simulating skin texture and preparation method thereof

A wound repair and skin structure technology, applied in the fields of medical science, absorbent pads, prostheses, etc., can solve the problems of immune rejection, insufficient donors, etc., and achieve the effect of promoting synthesis, good absorption, and good hydrophilicity

Active Publication Date: 2014-05-07
赣江新区莱威再生医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are problems such as immune rejection and insufficient donors.

Method used

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  • Composite membrane for promoting wound repair by simulating skin texture and preparation method thereof
  • Composite membrane for promoting wound repair by simulating skin texture and preparation method thereof
  • Composite membrane for promoting wound repair by simulating skin texture and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (a) Collagen (Col), chitosan (CS) and 2-methacryloxyethyl phosphorylcholine (MPC) were dissolved in hexafluoroisopropanol at a mass ratio of 65:20:15 In the solvent, the total mass volume concentration of collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) is 70mg / ml, stirred to a homogeneous solution;

[0043] (b) Pour the solution obtained in step (a) into a polytetrafluoroethylene mould. After the solvent volatilizes, the film can be removed to obtain a dense composite film, which is placed in a vacuum at -0.1MPa and a temperature of 120° Dry in a vacuum drying oven for 48 hours to promote the complete evaporation of the solvent;

[0044] (c) After the dried composite film of step (b) is placed in a desiccator and cross-linked with glutaraldehyde steam for 36 hours, the cross-linked composite film is placed in distilled water and washed for 3 days until the glutaraldehyde in the composite film is washed. The dialdehyde is completely remo...

Embodiment 2

[0048] (a) Collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were dissolved in hexafluoroisopropanol at a mass ratio of 55:25:20 In the solvent, the total mass volume concentration of collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) is 80 mg / ml, stirred to a homogeneous solution;

[0049] (b) Pour the solution obtained in step (a) into a polytetrafluoroethylene mold. After the solvent volatilizes, the film can be removed to obtain a dense composite film, which is placed in a vacuum with a vacuum degree of -0.1MPa and a temperature of 120°. Dry in a drying oven for 48 hours to promote the complete evaporation of the solvent;

[0050] (c) After the dried composite film of step (b) is placed in a desiccator and cross-linked with glutaraldehyde steam for 48 hours, the cross-linked composite film is placed in distilled water and washed for 3 days until the glutaraldehyde in the composite film is washed. The dialdehyde ...

Embodiment 3

[0055] (a) Collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were dissolved in hexafluoroisopropanol at a mass ratio of 45:30:25 In the solvent, the total mass volume concentration of collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) is 90 mg / ml, stirred to a homogeneous solution;

[0056] (b) Pour the solution obtained in step (a) into a polytetrafluoroethylene mould. After the solvent volatilizes, the film can be removed to obtain a dense composite film, which is placed in a vacuum at -0.1MPa and a temperature of 120° Dry in a vacuum drying oven for 48 hours to promote the complete evaporation of the solvent;

[0057] (c) After the dried composite film of step (b) is placed in a desiccator and cross-linked with glutaraldehyde steam for 60 hours, the cross-linked composite film is washed in distilled water for 3 days until the glutaraldehyde in the composite film is washed. The dialdehyde is completely removed, an...

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Abstract

The invention discloses a composite membrane for promoting wound repair by simulating a skin texture and a preparation method thereof. The preparation method comprises the following steps that: dissolving collagen (Col), chitosan (CS) and 2-methacryloyloxyethyl phosphorylcholine (MPC) at a mass ratio of (45-65):(20-30):(15-25) in a hexafluoroisopropanol solvent, and stirring into a homogeneous phase solution; pouring the homogeneous phase solution into a polytetrafluoroethylene mould, demoulding after volatilizing the solvent so as to obtain a compact composite membrane, and drying in a vacuum drying oven to completely volatilize the solvent; placing the dried composite membrane into a dryer to crosslink by glutaraldehyde vapor; cleaning the cross-linked composite membrane in water until removing glutaraldehyde in the composite membrane, and then vacuum drying the composite membrane to remove moisture; punching a plurality of through holes on the vacuum dried composite membrane by utilizing laser drilling, wherein the diameter of the through holes is 0.1-0.2 mm, and the space between the through holes is 0.8-1.2 mm, thereby obtaining the composite membrane for promoting the wound repair by simulating the skin texture.

Description

Technical field: [0001] The invention belongs to the field of biologically active materials, and relates to a skin wound repair and regeneration material and a preparation method thereof, in particular to a composite membrane for promoting wound repair by simulating skin structure and a preparation method thereof. Background technique: [0002] At present, the number of people with skin trauma is as high as 40 million in the world every year, and there is no ideal skin wound repair product that can meet clinical needs at home and abroad, especially ulcers caused by bedsores, varicose veins, vasculitis, diabetes, etc., are difficult to cure. It not only seriously affects the skin barrier function and appearance, but also may cause systemic metabolic disorder, infection and even the threat of death. However, traditional wound treatment techniques, including standard debridement and dressing, scab removal, wound decompression, and treatment of underlying lesions, are not ideal ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/56A61L27/24A61L27/20A61L15/32
Inventor 林才李彬
Owner 赣江新区莱威再生医学科技有限公司
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