Application and preparation method of compound madopar to preparation of information therapeutic medicine and novel medicine prepared from compound madopar

Abstract

The invention discloses an application and a preparation method of a compound madopar to preparation of an information therapeutic medicine and a novel medicine prepared from the compound madopar. The information therapeutic medicine is indirect with a human body during therapy, so that material components of the information therapeutic medicine cannot be consumed, a chemical treatment effect can be achieved by only using medicine information physical therapy; and a therapy window of the information therapeutic medicine is enlarged by above thousands, and thus side effects of chemical therapy are avoided. After the madopar is used as the information therapeutic medicine, contents of effective components are not changed, and the information therapeutic medicine can be used as a chemical therapeutic conventional preparation to be secondarily and effectively used.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a novel medicine of Madopa. Background technique [0002] The compound Madopa, also known as dopaserazide, is a complex of levodopa and benserazid Hydrochloride (Levodopa and Benserazid Hydrochloride), which is 3-(3,4-dihydroxyphenyl-L-alanine and 2- [2,3,4-Trihydroxyphenyl]methyl)hydrazide-DL-serine salt, chemical formula: levodopa C 9 h 11 NO 4 , benserazide C 10 h 16 ClN 3 o 5 , molecular weight levodopa 197.19, benserazide 293.7. The properties are white crystalline powder, almost odorless and tasteless. Madopar is an anti-Parkinson drug, clinically used for the treatment of Parkinson's disease and Parkinson's syndrome. The pharmaceutical preparations of Madopar include tablets, capsules, etc. The known Madopa drugs are all used as chemotherapeutic drugs, which allow the compound Madopa molecules to enter the human body (through oral absorption into the blood), distribute t...

AI Technical Summary

Problems solved by technology

In the prior art, Medopa has insurmountable defects as a chemotherapeutic drug. The first is its toxic and side effects on the human body, and its nasty adverse reactions include nausea and vomiting, orthostatic hypotension, head and face tongue and abnormal involuntary movements of the upper limbs and upper parts of the body, mental depression, dysuria, high blood pressure, and arrhythmia; second, the treatment window is small, and due to the toxic and side effects on the human body, the effective dose that can be used is very small, which limits the therapeutic effect , the maximum dose of oral administration is 0.5g once, 1g a day, if the maximum dose is exceeded, it can cause poisoning; the third is that there is only one use of chemotherapeutic drugs, and the drugs will be metabolized or excreted when they enter the human body, so they cannot be used twice

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