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External medicament for treating skin diseases and application thereof

A technology of beclomethasone dipropionate and topical drugs, applied in the field of biomedicine, can solve the problems that cannot be used at the same time, can only be used alternately, drugs cannot penetrate well, and are limited to the experimental exploration stage, etc., to achieve enhanced therapeutic effect, The therapeutic effect is remarkable and the effect of being easy to popularize and apply

Active Publication Date: 2014-06-11
济南龙华医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the inventor's many years of research and observation on dermatological drugs, it is found that long-term use of a single active ingredient drug has many disadvantages, such as: 1. When using a single drug, the drug dosage must be increased to ensure the curative effect, which will inevitably lead to obvious side effects of the drug Increase; 2. Existing drugs with a single component cannot be used at the same time, and can only be used alternately, that is, one drug is applied to the affected area first, and then another drug is applied after it is fully absorbed, so that the drug cannot penetrate well, which is a waste of money There is not enough curative effect, and this method of medication is only limited to the stage of experimental exploration, and there is no such method of use in practical application

Method used

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  • External medicament for treating skin diseases and application thereof
  • External medicament for treating skin diseases and application thereof
  • External medicament for treating skin diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Beclomethasone dipropionate 0.05g, adapalene 0.01g, petrolatum 700g, liquid paraffin 149.94g, lanolin 100g, stearic acid 50g.

[0030] Beclomethasone dipropionate and adapalene were crushed separately, dispersed evenly with liquid paraffin, and set aside. Heat and melt vaseline, lanolin, and stearic acid, and when cooled to 40°C-50°C, add beclomethasone dipropionate, adapalene, and liquid paraffin, stir evenly, and cool to obtain the product. Each gram of ointment contains 0.05 mg of beclomethasone dipropionate and 0.01 mg of adapalene.

Embodiment 2

[0032] Beclomethasone dipropionate 0.1g, adapalene 0.5g, petrolatum 700g, liquid paraffin 149.4g, lanolin 100g, stearic acid 50g.

[0033] Beclomethasone dipropionate and adapalene were crushed separately, dispersed evenly with liquid paraffin, and set aside. Heat and melt vaseline, lanolin, and stearic acid, and when cooled to 40°C-50°C, add beclomethasone dipropionate, adapalene, and liquid paraffin, stir evenly, and cool to obtain the product. Each gram of ointment contains 0.1 mg of beclomethasone dipropionate and 0.5 mg of adapalene.

Embodiment 3

[0035] Beclomethasone dipropionate 0.25g, adapalene 2.5g, petrolatum 700g, liquid paraffin 98.25g, solid paraffin 10g, lanolin 100g, simethicone 39g, stearic acid 50g.

[0036] Beclomethasone dipropionate and adapalene were crushed separately, dispersed evenly with liquid paraffin and simethicone oil, and set aside. Heat and melt vaseline, solid paraffin, lanolin, and stearic acid, and when cooled to 40°C-50°C, add beclomethasone dipropionate, adapalene, liquid paraffin, and simethicone, stir evenly, and cool. Instantly. Each gram of ointment contains 0.25 mg of beclomethasone dipropionate and 2.5 mg of adapalene.

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Abstract

The invention discloses an external medicament for treating skin diseases and an application thereof. The medicament consists of a pharmaceutically active component and a pharmaceutically-acceptable auxiliary material, wherein the pharmaceutically active component is a mixture of beclomeasone propionate and adapalene, or a mixture of beclomeasone propionate and abamectin A, or a mixture of beclomethasone, adapalene and abamectin A. Due to the adoption of the external medicament, the defects of poor curative effect of single administration and large side effect are overcome, and a compound external medicament is prepared by compounding beclomeasone propionate, adapalene or / and abamectin A. A preparation provided by the invention can be prepared into external dosage forms of different forms; and under the synergic actions and complementary actions of medicaments, the compound external medicament has an enhanced curative effect, untoward effects of patients are reduced in clinical application, the treatment effects on skin diseases are remarkable, and the external medicament is easy to accept for patients.

Description

technical field [0001] The invention relates to a medicine for external use for treating skin diseases and an application thereof, in particular to a compound medicine for external use containing beclomethasone dipropionate and adapalene or / and acitretin and an application thereof, belonging to the technical field of biomedicine. Background technique [0002] Dermatosis is a disease related to the skin, and is one of common diseases and frequently-occurring diseases that have a strong impact on people's health, and it has multiple types. [0003] Allergic skin diseases are skin diseases caused by allergens. Specific allergens can be divided into four categories: contact allergens, inhalation allergens, ingestion allergens, and injection allergens. [0004] Eczema is a common inflammatory skin disease of the epidermis and superficial dermis caused by various internal and external factors. [0005] Allergic dermatitis is a skin disease caused by allergens. It mainly refers to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K31/192A61K31/203A61P17/00
Inventor 李菁徐彦许东升王浩骅马全龙韩丽丽孙山梁海勇
Owner 济南龙华医药技术有限公司
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