Anti-tumor saponin in anemone plants and preparation method thereof as well as application

Anemone genus, anti-tumor technology, applied in the field of medicine, to achieve the effect of high yield
CN102603856AActive Publication Date: 2012-07-25SHENYANG PHARMA UNIVERSITY +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHENYANG PHARMA UNIVERSITY
Publication Date
2012-07-25

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Abstract

The invention relates to a preparation method of a triterpenoid saponin compound in anemone plants and a mechanical application, in particular relates to an anti-tumor application. The molecular formula of the compound is C47H76O16, and a chemical name of the compound is oleanolic acid-3-0-alpha-L-rhamanopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->4)]-alpha-L-arabinopyranosid. The extraction preparation process of the compound disclosed by the invention is applicable to the industrial production and can be used for converting other saponin compounds in medicinal materials into the saponin through an alkaline hydrolysis production, so that the content of the target saponin compound is greatly improved. Shown by anti-tumor experiments in vivo and vitro, the compound plays a role in suppressing a plurality of kinds of tumor cells to generate, and approximately has no suppression and toxic actions on generation of normal cells. Therefore, the triterpenoid saponin compound can be used for treating tumor diseases.
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Description

technical field

[0001] The invention relates to the technical field of medicine, and relates to a compound with antitumor activity obtained by extracting and isolating plants of the genus Anemone and its application in antitumor. Background technique

[0002] Cancer is a common disease with increasing morbidity and mortality every year. However, there is no effective method and drug to cure it. Therefore, it has become a hot spot to find a safe anti-cancer drug with low toxicity and side effects through the development of natural products.

[0003] Anemone is the largest genus in Ranunculaceae (Ranunculaceae), with a total of more than 150 species of plants distributed all over the world. There are more than 50 species of anemone plants in my country, which are distributed in all provinces except Hainan Island. Anemones have a long history of medicinal use in my country, and there are many types of medicinal plants of this genus among the people, with a wide range of effec...

Claims

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