Thermo-sensitive chain extender and polyurethane hydrogel with double sensitivity of temperature and pH
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A temperature-sensitive chain extender, hydrogel technology, applied in the field of polyurethane hydrogel, can solve the problems of affecting polyurethane biocompatibility, difficult material properties, temperature-sensitive variable separation research, etc.
Inactive Publication Date: 2012-07-25
SOUTH CHINA UNIV OF TECH
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[0003] At present, most temperature- and pH-sensitive polyurethane hydrogels are prepared by persulfate-induced crosslinking of polyacrylate and N-isopropaneacrylamide. The polyurethane hydrogel prepared by this method is only part of the structure. It has a polyurethane molecular chain, not a pure polyurethane hydrogel, which affects the biocompatibility of polyurethane to a certain extent
In addition, by stimulating double bond cross-linking, due to the problem of proportion, it is difficult to conduct variable separation research on the performance and temperature sensitivity of the cross-linked material
Method used
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Embodiment 1
[0042] A preparation method of temperature-sensitive chain extender, comprising the following steps:
[0043] Add 80 parts of N-isopropane acrylamide, 20 parts of ethylenediamine and 0.01 part of sodium ethoxide into a single-necked round-bottomed flask, use 10 g of ethanol as a solvent, place it in an electromagnetic stirrer and stir thoroughly, and heat to 80°C. After the ethanol vapor removes the air, seal the flask, keep it at 80-85°C, take out the ethanol after 4-6 hours, and drain the ethanol to obtain a temperature-sensitive chain extender. Said parts are parts by weight.
Embodiment 2
[0045] A preparation method of temperature-sensitive chain extender, comprising the following steps:
[0046] Add 65 parts of N-isopropaneacrylamide, 35 parts of ethylenediamine and 0.01 part of sodium methoxide into a single-necked round-bottomed flask, use 10 g of ethanol as a solvent, place it in an electromagnetic stirrer and stir thoroughly, and heat to 80°C. After the ethanol vapor removes the air, seal the flask, keep it at 80-85°C, take out the ethanol after 4-6 hours, and drain the ethanol to obtain a temperature-sensitive chain extender. Said parts are parts by weight.
Embodiment 3
[0048] A preparation method of temperature-sensitive chain extender, comprising the following steps:
[0049] Add 75 parts of N-isopropane acrylamide, 25 parts of ethylenediamine and 0.01 part of sodium hydroxide into a single-necked round bottom flask, use 10g of ethanol as a solvent, place it in a magnetic stirrer and stir thoroughly, and heat to 80°C , after the ethanol vapor removes the air, seal the flask, keep it at 80-85°C, and take out the ethanol after 4-6h to obtain a temperature-sensitive chain extender. Said parts are parts by weight.
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Abstract
The invention discloses a thermo-sensitive chain extender and polyurethane hydrogel with double sensitivity of temperature and pH. The hydrogel is prepared by the following methods: mixing 15-20.6 percent of polyethylene glycol, 6.7-9.2 percent of polyhydric carboxylic acid, 25.2-34.6 percent of multi-isocyanate and dibutyltin dilaurate used as a catalyst to perform pre-condensation polymerization reaction; adding organic solvent to stop reaction to obtain a pre-polymer; adding 15.3-36.5 percent of a thermo-sensitive chain extender to perform chain extension reaction; adding 3.1-4.3 percent of polyhydric alcohol amine stop end after the pre-polymer is subjected to the chain extension; and then, adding 11.6-19.4 percent of a curing crosslinking agent to perform crosslinking reaction to obtain polyurethane hydrogel with double sensitivity of temperature and pH. The thermo-sensitive chain extender is prepared by the method, and a method for introducing the thermo-sensitive chain extenderin polyurethane is provided, and the softness and hardness of the material are controlled in a post-crosslinking mode, so that the defects that introduction of groups and cross-linking solidity are carried out at the same time in the conventional way of excitation of double bonds are overcame, and the polyurethane hydrogel with double sensitivity of temperature and pH is prepared.
Description
technical field [0001] The invention relates to a temperature-sensitive chain extender and a temperature- and pH-sensitive polyurethane hydrogel. Background technique [0002] Polyurethane (PU) has good biocompatibility and excellent physical and mechanical properties. It has good physiological acceptability to the human body and can maintain the stability of long-term human implantation. The surface of the hydrogel is not easy to adhere to proteins and cells, so it will show good biocompatibility when in contact with blood, body fluids and human tissues; in addition, the hydrogel is very soft because it contains a large amount of water, and is similar to In biological tissues, it can reduce adverse reactions as a human implant. Most polyurethane hydrogels have environmental responsiveness. According to the response to external stimuli, hydrogels can be divided into: temperature-responsive hydrogels, pH-responsive hydrogels, light-responsive hydrogels, Pressure-responsive...
Claims
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