Preparation and application of insoluble drug-entrapped poloxamer/amphiphilic polysaccharide mixed micelle

Abstract

The invention discloses preparation and application of an insoluble drug-entrapped poloxamer / amphiphilic polysaccharide mixed micelle. The insoluble drug-entrapped poloxamer / amphiphilic polysaccharide mixed micelle is prepared through a dialysis method or a solvent evaporation method. The mixed micelle is low in critical micelle concentration, is high in drug-loading rate, is capable of obviously prolonging the stabilization time and has the long-circulation function of a nanomicelle and has dual functions of restraining the metabolism of P-glycoprotein and cytochrome P450 enzyme and is capable of increasing the bioavailability of oral administration. The mixed micelle is simple in preparation method, is mature in process and is high in yield and can be prepared into preparations for the oral administration, such as tablets, capsules, pills and syrups.

Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and relates to a preparation method of poloxamer / amphiphilic polysaccharide mixed micelles for insoluble drugs and its application in oral administration. Background technique

[0002] Oral administration is the most common way of administration among many routes of administration, because it is easy to take and carry, and is easily accepted by general patients, especially for those patients who need long-term or daily medication, the compliance of oral administration of drugs Sex is much better than other routes of administration. In addition, in order to reduce toxic and side effects, oral administration of cytotoxic agents is more suitable for long-term administration than injection administration, and can achieve better disease treatment effects.

[0003] For drugs that can be administered orally, their active ingredients should first be dissolved in the fluid of the human gastroin...

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