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Biological chip-based antidepressant drug curative effect risk evaluating system and application thereof

A risk assessment system and biochip technology, which is applied in the field of antidepressant drug efficacy risk assessment system, can solve the problems that have not yet appeared in the field of antidepressant drug efficacy assessment

Inactive Publication Date: 2012-08-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past ten years, fuzzy reasoning research has received enough attention in the frontiers of medical development and played an important role, but there has been no similar application in the field of antidepressant drug efficacy evaluation

Method used

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  • Biological chip-based antidepressant drug curative effect risk evaluating system and application thereof
  • Biological chip-based antidepressant drug curative effect risk evaluating system and application thereof
  • Biological chip-based antidepressant drug curative effect risk evaluating system and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] 1. Enrollment and evaluation of clinical patients:

[0080] 1. Inclusion criteria:

[0081] Included in the group are Chinese Han depression patients who meet the diagnostic criteria of DSM-IV unipolar depression, Hamilton Depression Scale (HAMD-17) score ≥ 18, 18-60 years old, male or female, first-episode or relapse, and all of them signed the informed consent , approved by the Ethics Committee.

[0082] 2. Exclusion criteria:

[0083] Strictly exclude those with a history of schizophrenia, alcohol and drug dependence; those with a history of brain organic diseases and endocrine diseases; those with abnormal blood, heart, liver, and kidney functions after examination; pregnant and breastfeeding women; those with mania or hypomania Attack history; depressive episodes accompanied by psychotic symptoms; electroconvulsive therapy.

[0084] 3. Clinical evaluation:

[0085]3.1. Clinical data collection: name, gender, age, age of onset, frequency of onset, total course o...

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Abstract

The invention relates to a biological chip, in particular to a biological chip-based antidepressant drug curative effect risk evaluating system. The biological chip-based antidepressant drug curative effect risk evaluating system is characterized by consisting of a biological chip, a study optimizing module, a curative effect evaluating module, a database management module and a clinical case management module. The biological chip in the invention has the capability of continuous studying and optimizing, the application and the popularization of the biological chip in the invention provide an explicit and convenient means for forecasting the clinical treatment effect of the depression, and a far-reading social influence is generated.

Description

technical field [0001] The present invention relates to a biochip, in particular to a risk assessment system for the curative effect of antidepressant drugs based on a biochip Background technique [0002] Depression (Major depression disorder, MDD) is a mood disorder characterized by persistent depression or loss of interest. According to WHO disability adjustment years, the disability caused by it ranks second among human diseases, and the lifetime prevalence rate is as high as 15%-17%, 15%-25% of patients finally succeed in suicide, and most patients have recurrent disease course. Therefore, clinical treatment highly emphasizes the importance of standard, whole-course and even life-long application of antidepressants. [0003] Since the advent of Selective 5-HT Reuptake Inhibitors (SSRIs) in the 1980s, various new antidepressants have been widely used clinically due to their overall clinical safety and good tolerance. There are very significant individual differences in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/34C12Q1/68G06F19/10
Inventor 张志珺韩正忠史艳艳徐治浦梦佳耿磊钰李东花小健李刚
Owner SOUTHEAST UNIV
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