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New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs)

An anti-hypertensive and new technology technology, applied in the field of medicine, can solve the problems of not showing the characteristics and advantages of hypertension, not reflecting the effect of anti-hypertensive traditional Chinese medicine on improving microcirculation, not reflecting the prognosis of hypertension and its complications, etc. , to achieve a wide range of effects

Inactive Publication Date: 2012-08-22
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the evaluation of the curative effect of antihypertensive traditional Chinese medicine generally adopts the change of arterial blood pressure before and after the administration of chemical drugs. This method cannot reflect the improvement effect of antihypertensive traditional Chinese medicine on microcirculation, nor can it reflect the prognosis of hypertension and its complications, let alone Demonstrate the characteristics and advantages of traditional Chinese medicine in treating hypertension

Method used

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  • New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs)
  • New technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1 The laser Doppler blood flow imaging technique was used to measure the blood flow of 1 cm at the base of the tail of the SHR in an awake state, and the influence of the traditional Chinese medicine compound Jimaitong on the microcirculation blood flow at the base of the tail of the SHR was observed. Take 50 spontaneously hypertensive rats, and randomly divide them into five groups, normal saline group (NS control), positive control group (captopril), Jimaitong high-dose group (jimaitong, 10g / kg), Jimaitongzhong Dosage group (jimaitong, 5g / kg), Jimaitong low-dose group (jimaitong, 2.5g / kg), nine rats in each group, before intragastric administration and 2, 4, 6, 8, 10 hours after administration This method measures the blood flow of microvessels, and the data adopts t test.

[0008] The results show that different doses of Jimaitong can improve the microvascular blood flow of SHR rats by intragastric administration in different degrees. The effect lasted until...

Embodiment 2

[0012] Example 2 Laser Doppler blood flow imaging technology was used to measure the microcirculatory blood flow value of fingernails of normal human beings, and simultaneously measure the blood pressure value to explore the correlation between the two. Select 50 volunteers aged 20 to 60, including 15 males and 35 females. According to the relevant requirements of human blood pressure measurement, the blood pressure was measured with the left hand, and the microcirculation blood flow value of the fingernail of the right hand. ~100mmHg, 101~111mmHg and 112~140mmHg are divided into three blood pressure levels. As the blood pressure level increases, the microcirculatory blood flow decreases accordingly, indicating that blood pressure and microcirculatory blood flow are negatively correlated. It shows that this new technology can be used to evaluate the efficacy of compound antihypertensive traditional Chinese medicine, and can further predict the effect of antihypertensive traditi...

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Abstract

The invention relates to new technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs). The effect of the antihypertensive TCMs on improving microcirculation is evaluated through measurement of microvessel blood flow and the curative effects of the TCMs on treating hypertensive diseases and improving prognosis of the complications are further evaluated. The microvessel blood flow can be rapidly, intuitively and effectively measured by measuring the microvessel blood flow volume with a speckle full-frame real-time scanning imaging system in a non-contact and nondestructive manner and generating color images corresponding to measured areas in different perfusions. The new technology can be widely applicable to microcirculation of body surface parts of human bodies and common experimental animals and provides a more valuable basis for comprehensively evaluating the efficacy of the antihypertensive medicines.

Description

technical field [0001] The invention belongs to the technical field of medicine, and the invention relates to a new technology for evaluating the efficacy of antihypertensive traditional Chinese medicine, and mainly relates to a measurement method of microvascular blood flow. Background technique [0002] Hypertension is a disease that seriously endangers human health and quality of life, and is one of the most important risk factors for myocardial infarction, heart failure, stroke, end-stage renal disease and peripheral vascular disease. The pathogenesis of hypertension is very complex, related to hemorheological changes, renal sodium retention, renin-angiotensin system, sodium transport, increased vascular reactivity and thickening of the vessel wall, the role of the sympathetic nervous system, vasodilator hormones, Neuropeptides, insulin resistance and so on. Microcirculation is the blood circulation in capillaries between arterioles and venules, and is the most basic st...

Claims

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Application Information

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IPC IPC(8): A61B5/026
Inventor 吕圭源陈素红李丁苏洁
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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