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Pharmaceutical composition containing cefuroxime, preparation of composition, and preparation method of composition

A technology for cefuroxime and composition, which is applied in the field of pharmaceutical compositions containing cefuroxime and its preparation and preparation, can solve the problems of incapable or very few antibiotics, poor bactericidal effect, decreased affinity and the like, and improves drug resistance Problem, effect of good antibacterial effect

Active Publication Date: 2012-09-05
ZHUHAI UNITED LAB +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, MRSA (methicillin resistant Staphylococcusaureus) has multi-drug resistance, and its mechanism is the result of changes in PBPs. High drug resistance is due to the generation of a new PBP2' (ie PBP2a) between the original PBP2 and PBP3. Moderate drug resistance is caused by increased production of PBPs or decreased affinity with methicillin, etc.; the permeability of the bacterial cell wall or outer membrane changes, so that antibiotics cannot or rarely enter the bacterial body to reach the target site
The outer membrane of Gram-negative bacteria is the first barrier that restricts the penetration of β-lactam antibiotics into the bacteria; due to the lack of autolytic enzymes in bacteria, bacteria are resistant to antibiotics, that is, antibiotics have normal bacteriostatic effect, But the bactericidal effect is poor

Method used

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  • Pharmaceutical composition containing cefuroxime, preparation of composition, and preparation method of composition
  • Pharmaceutical composition containing cefuroxime, preparation of composition, and preparation method of composition
  • Pharmaceutical composition containing cefuroxime, preparation of composition, and preparation method of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Preparation of Cefuroxime Sodium Sterile Powder

[0026] Take 40g of cefuroxime sodium, add 230g of water for injection at 15°C, stir to dissolve, add 1.3g of activated carbon, decolorize for 30 minutes, filter, and then pass the filtrate through two-stage filter membranes (0.45um, 0.2um) for sterile filtration, and the filtrate Add it to 1418g of sterile acetone, cool to 10°C, stir slowly, grow crystals for 1 hour after crystals are precipitated, filter, and wash the filter cake twice with sterile acetone (47g×2). After discharging, the wet material is transferred into a vacuum dryer, and dried in vacuum at 45°C and 0.09MPa for 8h. Collect the materials to obtain 34.3 g of sterile cefuroxime sodium.

Embodiment 2

[0028] Preparation of Potassium Clavulanate Sterile Powder

[0029] Take 30g of potassium clavulanate, add 29g of water for injection, stir to dissolve, add 0.35g of activated carbon, decolorize and filter for 30 minutes, then pass the filtrate through two-stage filter membrane (0.45um, 0.2um) for sterile filtration, and add the filtrate to 980g In sterile n-butanol, cool down to 0° C., stir for 2 hours, filter, and wash the filter cake twice with sterile n-butanol (36 g×2). After discharging, the wet material is transferred into a vacuum dryer, and dried in vacuum at 30°C and 0.09MPa for 6h. Collect the material to obtain 25.8 g of aseptic potassium clavulanate.

Embodiment 3

[0031] Accurately weigh 1.00 g of cefuroxime sodium aseptic powder and 0.5 g of clavulanate potassium aseptic powder, mix them in a sterile environment, and fill them to make sterile powder for injection.

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Abstract

The invention relates to a pharmaceutical composition containing cefuroxime, a preparation of the composition, and a preparation method of the composition, wherein the pharmaceutical composition is used for treating bacterial infection. The pharmaceutical composition consists of the cefuroxime or salt or ester of the cefuroxime, and clavulanic acid or salt of the clavulanic acid, which are in a mass ratio being equal to 1:1-15:1. The pharmaceutical composition has a better antibacterial effect and solves the problem of pharmaceutical resistance caused by the independent use of the cefuroxime.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a cefuroxime-containing pharmaceutical composition for treating bacterial infection, a preparation and a preparation method thereof. Background technique [0002] β-lactam antibiotics are a class of antibiotics with a β-lactam ring in their chemical structure. These antibiotics have the advantages of strong bactericidal activity, low toxicity, wide indications and good clinical efficacy. However, with the widespread use of β-lactam antibiotics, the resistance rate of various bacteria to antibiotics is also increasing. The reasons for drug resistance are as follows: [0003] Bacteria produce β-lactamase (penicillinase, cephalosporinase, etc.) to hydrolyze and inactivate susceptible antibiotics; β-lactamase-stabilized broad-spectrum penicillins and second and third-generation cephalosporins produced by Gram-negative bacteria The mechanism of drug resistance is not because the antibiotic is...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/424A61K9/14A61P31/04
CPCY02A50/30
Inventor 彭韪王德刚
Owner ZHUHAI UNITED LAB
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