Synthetic method of fatty acid monoethanolamide

A technology for the synthesis of monoethanolamide, which is applied to the preparation of carboxylic acid amide, chemical instruments and methods, and the preparation of organic compounds, etc., can solve the problem of demanding labor protection and environmental protection, difficult amination of alcohol amide, and the preparation process Complicated problems, to achieve the effect of low material cost, simple equipment and simple process

Inactive Publication Date: 2012-09-19
科凯精细化工(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product of this method has high purity, but the preparation process is complicated, and methanol is required in the reaction, which makes the requirements for labor protection and environmental protection harsh; the second is to directly react fatty acid with monoethanolamine to prepare alcohol amide, which has the advantage of simple process, but in addition to forming In addition to the target product, more by-products will be produced, such as amino esters, amide esters, etc., under the action of basic catalysts, amidoesters can be quickly aminated by alcohol amines into alcohol amides, while amino esters are difficult to amine Alcoholamide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 720 parts of coconut oil fatty acid methyl ester (or coconut oil fatty acid methyl ester, palm kernel oil fatty acid methyl ester or palm oil fatty acid methyl ester, etc.) and 193 parts of monoethanolamine in proportion to the reactor, and add 7.2 parts of sodium methoxide under stirring , Seal the reaction kettle, slowly raise the temperature to 130°C, the vacuum degree is 0.04MPa, and the reaction time is 3 hours. The distilled methanol can be used to produce fatty acid methyl esters after being refined and purified in subsequent processes. Resource saving and zero waste discharge. In the coconut oil fatty acid monoethanolamide obtained by the synthesis reaction, the amide content is greater than 95%, the free amine content is less than 1%, and the free fatty acid content is less than 0.5%.

Embodiment 2

[0020] Add 705 parts of palm kernel oil fatty acid methyl ester and 193 parts of monoethanolamine in proportion to the reaction kettle, add 8.1 parts of sodium methoxide under stirring, seal the reaction kettle, slowly raise the temperature to 120°C, the vacuum degree is 0.03MPa, and the reaction time is 4 hours. The distilled methanol can be used for the production of fatty acid methyl esters after being refined and purified in the subsequent process, saving resources and zero waste discharge. The amide content of the palm kernel oil fatty acid monoethanolamide obtained by the synthesis reaction is greater than 95%, the free amine content is less than 1%, and the free fatty acid content is less than 0.5%.

Embodiment 3

[0022] Add 700 parts of palm oil fatty acid methyl ester and 193 parts of monoethanolamine in proportion to the reaction kettle, add 8.1 parts of sodium methoxide under stirring, seal the reaction kettle, slowly raise the temperature to 140°C, the vacuum degree is 0.05MPa, and the reaction time is 2 Hour. The distilled methanol can be used for the production of fatty acid methyl esters after being refined and purified in the subsequent process, saving resources and zero waste discharge. The amide content of the palm kernel oil fatty acid monoethanolamide obtained by the synthesis reaction is greater than 95%, the free amine content is less than 1%, and the free fatty acid content is less than 0.5%.

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PUM

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Abstract

The invention relates to a synthetic method of fatty acid monoethanolamide, and belongs to the technical field of the synthesis of amide compounds in the organic chemistry. The synthetic method comprises the following steps of: using fatty acid methyl ester and monoethanolamine as raw materials, and carrying out an amidation reaction under the action of a catalyst to prepare the fatty acid monoethanolamide, wherein the mol ratio of the fatty acid methyl ester to the monoethanolamine is 1: (1.0-1.1); the catalyst of the synthetic method is sodium methoxide or potassium hydroxide; and the dosage of the catalyst is 0.5-1.0% of the total mass percent of the fatty acid methyl ester and the monoethanolamine. By using the synthetic method, the 1: 1 type fatty acid monoethanolamide is synthesized by adopting a one-step method; the process is simple; and the material cost is low.

Description

technical field [0001] The invention describes a method for synthesizing fatty acid monoethanolamide, which belongs to the technical field of synthesis of amide compounds in organic chemistry. Background technique [0002] The general formula of alkanolamide is RCONHCH 2 -CH 2 OH, light yellow solid, non-toxic, non-irritating, with excellent thickening and foam stability, less dosage and better thickening and safety than 6501. Good compatibility, excellent synergistic effect and excellent emollient, fragrance, decontamination and hard water resistance. Not easily soluble in water, suitable for pearlescent products. At the same time, it also has emulsification and light-shielding properties, and is used for the preparation of pearlescent paste. Good biodegradability, the degradation rate can reach more than 97%. [0003] Based on the above characteristics, alkanolamides are often added to pearlescent shampoos, body washes, hand washes, laundry detergents, soaps, ointment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C233/20C07C233/18
Inventor 顾永欢樊小景胡仲飞吴爱花
Owner 科凯精细化工(上海)有限公司
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