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Beta-cyclodextrin clathrating technique for borneol in Saimeian emulsifiable paste

A cyclodextrin and borneol technology, which is applied in the field of β-cyclodextrin package and technology, can solve the problems of borneol content decline, unstable quality, borneol volatilization, etc.

Inactive Publication Date: 2012-09-26
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the problem of unstable quality is prone to occur in the prescription of Saimean ointment. The solubility of borneol in the water phase and oil phase is relatively small, and it is in a suspended state in the cream. During long-term storage, borneol is easy to volatilize and easily cause borneol content decreased

Method used

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  • Beta-cyclodextrin clathrating technique for borneol in Saimeian emulsifiable paste
  • Beta-cyclodextrin clathrating technique for borneol in Saimeian emulsifiable paste
  • Beta-cyclodextrin clathrating technique for borneol in Saimeian emulsifiable paste

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Dissolve borneol in an appropriate amount of ethanol, and dissolve β-cyclodextrin with 4 times the mass of borneol in purified water at 40°C to make a saturated solution; slowly pour the dissolved borneol into the saturated solution of β-cyclodextrin, at 40°C , stirred at a stirring speed of 600r / min for 2h, then placed at 4°C for 24 hours, then filtered with suction, and washed the clathrate with a small amount of ethanol to remove unincluded borneol; filtered again, and the obtained The clathrate was placed in a vacuum drying oven at 25 degrees Celsius and dried for 24 hours to obtain the β-cyclodextrin borneol clathrate.

Embodiment 2

[0031] Dissolve borneol in an appropriate amount of ethanol, and dissolve β-cyclodextrin with 6 times the mass of borneol in purified water at 43°C to make a saturated solution; slowly pour the dissolved borneol into the saturated solution of β-cyclodextrin, at 43°C , stirred at a stirring speed of 700r / min for 3h, then placed at 4°C for 24 hours, then filtered with suction, and washed the clathrate with a small amount of ethanol to remove unclathed borneol; filtered again, and the obtained The clathrate was placed in a vacuum drying oven at 25 degrees Celsius and dried for 24 hours to obtain the β-cyclodextrin borneol clathrate.

Embodiment 3

[0033] Dissolve borneol in an appropriate amount of ethanol, and dissolve β-cyclodextrin with 9 times the mass of borneol in purified water at 45°C to make a saturated solution; slowly pour the dissolved borneol into the saturated solution of β-cyclodextrin, at 45°C , stirred at a stirring speed of 900r / min for 4.5h, then placed at 4°C for 24 hours, then filtered with suction, and washed the clathrate with a small amount of ethanol to remove unincluded borneol; filtered again to obtain The clathrate was placed in a vacuum oven at 25 degrees Celsius and dried for 24 hours to obtain the clathrate of β-cyclodextrin borneol.

[0034] One of the verification schemes of the present invention:

[0035] Thin-layer chromatography: Weigh 130mg of β-cyclodextrin borneol inclusion complex, put it in a 15ml stoppered centrifuge tube, add 10ml of absolute ethanol, shake and mix, ultrasonicate for 20min, centrifuge at 3000r / min for 10min, and take the supernatant; Then take 100mg of borneol...

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Abstract

The invention provides a beta-cyclodextrin clathrating technique for borneol in Saimeian emulsifiable paste, which comprises the following steps: Step 10. dissolving borneol in a solvent, and taking beta-cyclodextrin to prepare a saturated water solution; Step 20. slowly adding the dissolved borneol in the Step 10 into the beta-cyclodextrin-containing saturated water solution, and stirring and mixing; and Step 30. cooling and standing the mixed solution obtained in the Step 20, and after finishing clathration, carrying out vacuum drying on the clathrated compound at the temperature of below 30 DEG C, thereby obtaining the beta-cyclodextrin borneol clathrated compound... The invention can enhance the stability of borneol, thereby keeping the drug properties of the Saimeian emulsifiable paste stable.

Description

【Technical field】 [0001] The invention relates to a β-cyclodextrin package and a process for borneol in Saimei'an cream. 【Background technique】 [0002] Saimei'an cream is a Chinese patent medicine, which can clear away heat and stop bleeding, astringent and dampness-dispelling, and rotten and granulation-promoting. For periodontal ulcers, skin bruises, knife wounds, chronic ulcers, cervical erosion, vaginitis, hemorrhoids, anal fistula, bedsores and other diseases. [0003] Borneol is hard in nature and flavor, slightly cold, has the functions of clearing all orifices, dispelling stagnant fire, removing nebula and improving eyesight, reducing swelling and alleviating pain. Treatment of apoplectic wind mouth silence, febrile coma, aphtha, otitis media, carbuncle, hemorrhoids, red eyes and cloudy membrane. At a higher concentration (0.5%), it can inhibit staphylococcus, streptococcus, pneumococcus, Escherichia coli and some pathogenic skin fungi. Combination with cinnabar ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/045
Inventor 王立强王雪玉
Owner HUAQIAO UNIVERSITY