Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Allose tablet excipient, medicinal tablet and method for preparing medicinal tablet

A technology of allulose tablets and excipients, which is applied in the field of medicine, can solve the problems of high fragility and inability to be pressed into tablets, and achieve the effects of high hydrophilicity, good molding degree, and high adhesion

Inactive Publication Date: 2012-10-03
安吉东来药用辅料有限责任公司
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Example 8, ordinary microcrystalline cellulose was used as an excipient to carry out tablet compression of disodium clometris phosphate tablet. When the tablet compression speed reached 30,000 tablets / hour, the friability was as high as 38%. When reaching 50000 tablets / hour, then can not be compressed into tablet; Carry out the disodium clomedate tablet tabletting with silicified microcrystalline cellulose as excipient, when the tabletting speed reaches 50000 tablets / hour, although the tablet is still Maintain good strength, but the brittleness reaches 2.5%, and the brittleness is still high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Allose tablet excipient, medicinal tablet and method for preparing medicinal tablet
  • Allose tablet excipient, medicinal tablet and method for preparing medicinal tablet
  • Allose tablet excipient, medicinal tablet and method for preparing medicinal tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0042]

[0043] Dry allose, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix well, use 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

Embodiment 2

[0045] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0046]

[0047] Dry allose, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix well, use 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

[0048] Prepare the anhydrous chlormedipate disodium pharmaceutical tablet (tablet A) of embodiment 1 and the anhydrous chlormedipate disodium pharmaceutical tablet (tablet B) of embodiment 2 under different tabletting speeds, and investigate Its crushing strength and fragility, the specific test results are shown in Table 1. The test of tablet crushing strength and friability refers to the method specified in the French Pharmacopoeia (10th edition in 1993, V.5.1) "Friability of Tablets".

[0049] Table 1

[0050] T...

Embodiment 3

[0053] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0054]

[0055] Dry allose, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloroformate and water and mix well, use 9× 20mm punching machine, made into anhydrous chlormedate disodium pharmaceutical tablets with an average weight of 1190mg (±2%).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an allose tablet excipient. The allose tablet excipient consists of the following components in percentage by weight: 88 to 96 percent of allose, 1 to 5 percent of starch octenyl succinate anhydride, 1 to 5 percent of silicon dioxide and 1 to 5 percent of kaolin, is high in fluidity, molding degree and demoulding performance, and can be directly compressed together with medicines and water to obtain medicinal tablets. The invention also discloses a medicinal tablet. The medicinal tablet consists of the following components in percentage by weight: 75 to 85 percent of medicinal active ingredient, 5 to 15 percent of allose tablet excipient and 5 to 15 percent of water raw material. The allose tablet excipient and the medicinal active ingredient do not have incompatibility and are reacted with each other; and the medicinal tablet is high in dissolvability and fluidity and is suitable for directly compressing various medicines. The invention also discloses a method for preparing the medicinal tablet. The method makes the medicinal tablets easily prepared and is easy to implement, operate and control.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an allose tablet excipient which can be directly compressed into tablets and is easy to flow, a drug tablet and a drug tablet prepared by using the allulose tablet excipient The preparation method of the agent. Background technique [0002] Tablet accounts for more than one-third of all pharmaceutical dosage forms and is a very important pharmaceutical dosage form. Excipients play a vital role in drug stability and absorption efficiency, and are the core of drug tablet making. Appropriate tablet excipients are required to be safe, non-toxic, have no side effects, have no incompatibility or reaction with the main drug, and have good fluidity, so that the main drug can be dispersed evenly and have a large adsorption force to the main drug. It is suitable for direct tablet compression. The prepared tablet has the advantages of high adhesion, good formability, good lubricity, good mold rele...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/26A61K47/02A61K31/663
Inventor 李青青阮晖吴慧斌刘松柏陈放诸文颖
Owner 安吉东来药用辅料有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com