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Application of novel polytetrafluoroethylene nano material

A technology of polytetrafluoroethylene and new materials, which is applied in the fields of medical science, prostheses, coatings, etc., to achieve the effect of improving the patency rate, improving the preparation method and reducing the degree of hyperplasia

Inactive Publication Date: 2012-10-03
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the application of a new type of polytetrafluoroethylene nanomaterial.

Method used

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  • Application of novel polytetrafluoroethylene nano material
  • Application of novel polytetrafluoroethylene nano material
  • Application of novel polytetrafluoroethylene nano material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of PTFE-MWNT

[0027] 1 experiment

[0028] 1.1 Raw materials and reagents

[0029] MWNTs (Shenzhen Nanometer Port Co., Ltd.) with a purity greater than 90% were used directly. PDDA solution (molecular weight: 200,000-350,000, Sigma-Aldrich, USA) was prepared into a 15 mg / ml ion solution. PTFE is taken from PTFE artificial blood vessel material imported from the United States, rubbed with sandpaper and treated with acetone and cut into 1cm 2 Use directly after size. Other chemicals and reagents were of analytical grade. The water used in the experiment was deionized water.

[0030] 1.2 Functionalization of MWCNTs

[0031] First, the MWNTs were dispersed in concentrated H 2 SO 4 / concentrated HNO 3 (3 / 1, v / v) in the mixed solution and stirred at 70°C for 4h. Then the obtained MWNT-COOH was repeatedly washed with water until neutral, and dried under vacuum at 70 °C for 12 h. Next, dry MWNT-COOH was added to SOCl at 70 °C 2 Stirred and ...

Embodiment 2

[0051] Example 2 Animal experiment of PTFE-MWNT

[0052] 1. Materials and methods

[0053] 1. Fabrication of PTFE-MWNT

[0054] 1.1 Functionalization of multi-walled carbon nanotubes

[0055] MWNTs (Shenzhen Nanoport Co., Ltd.) dispersed in concentrated H 2 SO 4 / Concentrated HNO 3 (3 / 1, v / v) mixed solution and stirred at 70°C for 4h. The obtained MWNT-COOH was then repeatedly washed with water until neutral, and dried under vacuum at 70 °C for 12 h. Next, dry MWNT-COOH was added to SOCl at 70°C 2 The reaction was stirred and refluxed for 24h, and the remaining SOCl was evaporated after the reaction was completed. 2 , the acyl chloride MWNTs were immediately added to NH 2 (CH 2 ) 2 NH 2 , the reaction was stirred and refluxed at 70 °C for 48 h. The obtained MWNT-NH was then treated with ethanol solution and water, respectively. 2 It was filtered and washed several times, and then dried under vacuum at 70 °C for 24 h for use.

[0056] 1.2 Layer-by-layer self-ass...

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Abstract

The invention relates to application of a novel polytetrafluoroethylene nano material in preparation of artificial blood vessels. A preparation method for the novel material comprises that self-assembling a functional multi-walled carbon nano tube (MWNT) film layer by layer on a polytetrafluoroethylene substrate. The invention also provides the application of the novel polytetrafluoroethylene (PTEF) nano material in preparation of the artificial blood vessels. The invention has the advantages that the MWNT film is obtained on the PTEF substrate pretreated by phthalic diglycol diacrylate (PDDA) through layer-by-layer self-assembly; by the simple preparation method, the performance of the substrate material can be well improved, and the self-assembled MWNT film using PTEF as the substrate is widely applied; and MWNT is combined with a PTEF blood vessel material massively used in clinic at present, so that postoperative endangium hyperplasia degree of artificial blood vessel implantation can be lightened in animal experiments, the patency rate of the blood vessels is improved, and a feasible method is provided for improving the curative effect of artificial blood vessel implanting operation in clinic.

Description

technical field [0001] The present invention relates to the application of a new nano material, in particular, the application of a new nano material of polytetrafluoroethylene. Background technique [0002] The excellent properties of PTFE have made it the most widely used material for artificial vascular grafts over the past few decades. PTFE artificial blood vessels are widely used to establish arteriovenous connections in hemodialysis patients. The most common arteriovenous connection in chronic hemodialysis patients is the use of PTFE vascular materials, accounting for 83% of all dialysis patients. In the United States alone, hundreds of thousands of patients need to apply each year. At the same time, many peripheral vascular diseases and congenital heart diseases require the use of artificial blood vessels for reconstruction or shunt surgery. In addition, in the absence of autologous blood vessel sources, some coronary artery bypass surgery also requires the use of P...

Claims

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Application Information

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IPC IPC(8): A61L27/40C08J7/06
Inventor 梅举鲍春荣
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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