Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing sodium tauroursodeoxycholate

A technology of sodium tauroursodeoxycholate and tauroursodeoxycholic acid, which is applied in the field of medicine, can solve the problems of difficult separation and purification and low cost, and achieve the effects of simple process, low cost and reduced production cost

Active Publication Date: 2012-10-10
HANGZHOU BAOJI BIO TECH
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention proposes a preparation method of sodium tauroursodeoxycholate, which solves the technical problem of difficult separation and purification in the prior art, and the method is simple and low in cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing sodium tauroursodeoxycholate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of sodium tauroursodeoxycholate, comprising:

[0032] (1) 10g of ursodeoxycholic acid raw material (25.5mmol), 2.7g of triethylamine (26.5mmol) dissolved in 100ml of acetone solution, cooled to -5~-10°C, and 2.9g of ethyl chloroformate was added dropwise to the solution Esters (25.97mmol), continue to stir at -5~-10°C for 20min after the dropwise addition, remove the triethylamine salt by filtration, and use the filtrate for later use;

[0033] (2) Condensation reaction of taurine

[0034] Dissolve 4g (31.875mmol) of taurine in 22ml of 1mol / L sodium carbonate solution, add dropwise to the mixed acid anhydride solution obtained in the previous item, add it at a uniform speed within 30min at 20-30°C, stir rapidly for 3h-4h, Filter out the precipitate, and the filtrate is for subsequent use;

[0035] (3) Acid adjustment and concentrated drying

[0036] The above-mentioned filtrate is adjusted to pH 6-7 with 2mol / L HCL solution, the solution is recov...

Embodiment 2

[0043] The large-scale production process of sodium tauroursodeoxycholate of the present invention will be further described below by taking the scale-up production of pilot scale as an example.

[0044](1) Dry the 150L reaction kettle, put in 90L of anhydrous acetone, put in 10kg of ursodeoxycholic acid under stirring and wait for the dispersion to be uniform, the refrigeration pump is preset at -20°C for cold circulation until the temperature in the kettle drops to At -5°C, dilute 2.7kg of triethylamine with 2L of acetone, then add dropwise with a constant pressure funnel, drop it at a constant speed within 20 minutes, keep the temperature in the kettle at -5°C ~ -10°C, rinse with 2L of acetone at constant pressure Funnel, take 2.9kg of ethyl chloroformate diluted with 2-3L of acetone, add it to the constant pressure funnel, drop it into the reaction kettle within 1h, keep the temperature at -3℃~-5℃ for 20min, release the reaction solution and filter to remove the amine Prec...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for preparing sodium tauroursodeoxycholate. The method comprises (1) using ursodesoxycholic acid as raw materials and getting a mixed anhydride solution through acetylation and chloride reactions; (2) dissolving taurine into a sodium carbonate solution to get a taurine sodium carbonate solution which is then added in drops into the mixed anhydride solution of step (1) with stirring, and then filtering precipitate to get a filtrate; (3) adjusting pH of the filtrate of step (2) to 6 to 7, concentrating and drying to get crude dried products of tauro-ursodesoxycholic acid; and (4) desalting purifying and re-crystallizing the concentrated dried products of step (3) to get the sodium tauroursodeoxycholate. The method is low in cost and short in technology route, with a yield up to 78%, and is suitable for industrial scale production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a preparation method of sodium tauroursodeoxycholate. Background technique [0002] Tauroursodeoxycholic acid (tauroursodeoxycholic acid) is the main active ingredient of bear bile, and also the main ingredient of artificially synthesized bear bile. It is a combined bile acid widely present in the bile of humans and various animals, and has a variety of physiological and pharmacological properties. The drug and its preparations have been marketed in foreign countries for 20 years and are mainly used for steroid gallstones, cholestatic liver disease (such as primary biliary cirrhosis), bile reflux gastritis, Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), chronic hepatitis (hepatitis B, hepatitis C, etc.), alcoholic fatty liver, nonalcoholic fatty liver, Drug-induced liver damage, prevention and treatment of complications before and after...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07J41/00
Inventor 江崇波
Owner HANGZHOU BAOJI BIO TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com