Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Use of silymarin in preparations of drugs for treatment of Alzheimer's disease

A technology for senile dementia and silybin, applied in the field of medicine, can solve problems such as the treatment effect of central nervous system diseases that do not involve the mechanism of action of the central nervous system, and achieve improved cognitive ability and quality of life, with definite curative effect and low side effects Effect

Inactive Publication Date: 2012-10-17
SUN YAT SEN UNIV
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application 201010238453.X discloses the use of milk thistle or silybin for the treatment of nerve damage. This patent application has confirmed that silybin has a positive therapeutic effect on spinal cord injury and spinal cord-related diseases, but the The patent application does not involve its mechanism of action on the central nervous system and its therapeutic effect on central nervous system diseases
According to the existing technologies retrieved so far, there are still relatively few studies on the role of silibinin in the nervous system at home and abroad at this stage, especially in the study of central nervous system degenerative diseases.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of silymarin in preparations of drugs for treatment of Alzheimer's disease
  • Use of silymarin in preparations of drugs for treatment of Alzheimer's disease
  • Use of silymarin in preparations of drugs for treatment of Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Silybin tablet preparation

[0022]

[0023] Preparation process: Weigh the prescription amount of silybin, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 60% ethanol, add it to the mixed powder, mix it evenly to make a soft material, granulate it through a 16-mesh sieve, and dry it below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 2

[0024] Embodiment 2 Silybin Tablet Preparation

[0025]

[0026]

[0027] Preparation process: Weigh the prescription amount of silibinin, microcrystalline cellulose and hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 8% starch slurry solution, add it to the mixed powder, mix evenly to make soft material, pass through a 16-mesh sieve to granulate, and dry below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

Embodiment 3

[0028] Embodiment 3 silybin tablet preparation

[0029]

[0030] Preparation process: Weigh the prescription amount, silybin, starch, dextrin and low-substituted hydroxypropyl cellulose and mix evenly. Take another appropriate amount of 60% ethanol, add it to the mixed powder, mix it evenly to make a soft material, granulate it through a 16-mesh sieve, and dry it below 60°C. After drying, use an 18-mesh sieve to carry out granulation, sieve out the fine powder in the dry granules, mix with the sieved magnesium stearate, and then mix with the dry granules evenly, and press into tablets to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a use of silymarin in preparations of drugs for prevention or treatment of Alzheimer's disease, and belongs to the field of medicine. When silymarin is used for treatment or prevention of human or mammalian Alzheimer's diseases, the silymarin can be adopted as the drug separately, and can further be combined with other drugs for treatment of Alzheimer's disease, wherein action mechanisms of other drugs for treatment of Alzheimer's disease are different to the action mechanism of the silymarin, and the drug combination can provide effects of reducing of toxic and side effects of drugs and synergistic therapeutic effect. The silymarin can significantly inhibit beta amyloid deposition, and provides definite therapeutic effect and low side effects for prevention or treatment of Alzheimer's disease so as to provide broad medicine application prospects.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of a known drug, in particular to the application of silibinin in the preparation of a drug for treating senile dementia. Background technique [0002] Alzheimer's disease, also known as Alzheimer's disease (Alzhimer's Disease, AD), is a degenerative disease of the central nervous system. Various schizophrenic symptoms and behavioral disturbances. With the development of the disease, patients will gradually lose their ability to take care of themselves, which will bring a heavy burden to the patient's personal family and society. Prevalence research shows that the number of Alzheimer's cases in the United States in 2000 was 4.5 million, and the percentage of Alzheimer's disease patients will increase by 2 times for every 5 years of age increase. The prevalence rate is 6%, compared with 30% in the 85-year-old population. At present, there are about 129 million people over...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/357A61K45/00A61P25/28
Inventor 顾怀宇段松伟方少亮陈雪曼陈树敏乔景达
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com