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Method for preparing micro-solution storage and multi-phase heterogenous microparticles

A memory and dissimilarity technology, applied in microstructure technology, microstructure devices, manufacturing microstructure devices, etc., can solve the problem of inability to form dual-phase or multi-phase microparticles, non-uniform microparticle size, and difficulty in achieving monodisperse characteristics and other problems, to achieve the effect of adjustable quantity, uniform particle size and controllable shape

Inactive Publication Date: 2012-10-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Application Information

AI Technical Summary

Problems solved by technology

Conventional methods can easily synthesize polydisperse hydrogel microparticles, but the particle size is not uniform, it is difficult to achieve monodisperse characteristics, and it is impossible to form stable monodisperse two-phase or multi-phase microparticles

Method used

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  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles
  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles
  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of hydrogel microsolution reservoir containing single oil core content and two-phase and two-sided heterotropic microparticles:

[0028] The schematic diagram of the microfluidic chip used in the preparation is as follows: figure 1 shown. Firstly, the microfluidic chip with channels on the upper layer is prepared by soft lithography technology, and then it is irreversibly sealed with the lower substrate by oxygen plasma.

[0029] The stable double emulsion micro-droplets can be formed by hydrophobizing and hydrophilizing the surface of the channel. Then an external peristaltic pump is used to drive different solutions. The isopropylacrylamide monomer solution enters the water phase microchannel 2, the dispersed oil core phase (mineral oil) enters the dispersed oil core phase microchannel 1, and the continuous oil phase (FC-40) enters the continuous oil phase microchannel 3, and its flow rate is adjusted to 0.9 μL / min, 0.01 μL / min, and 3.0 μL / min respective...

Embodiment 2

[0032] Hydrogel microsolution storage of complex oil core content and preparation of heterogeneous microparticles with multi-phase and multi-facets:

[0033] Preparation of chips used and control of various fluids such as figure 1As shown, when the flow rates of isopropylacrylamide solution, mineral oil and FC-40 are 0.9 μL / min, 0.03 μL / min, and 3.0 μL / min, two oils can be included in the formation of double emulsion microdroplets. core, and then polymerized into a hydrogel microsolution reservoir containing two oil core contents, when the flow rate of mineral oil was adjusted to 0.05 μL / min, a microsolution reservoir containing three oil core contents could be formed, like Figure 4 Shown are the formed microsolution reservoirs with two (A to C) and three (D to F) oil core inclusions and their oil core release upon addition of water. Natural dehydration of multiple inclusions at room temperature will form two-phase three-sided heterogeneous microparticles (such as Figure ...

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Abstract

The invention provides a method for preparing a hydrogel micro-solution storage device and multi-phase heterogenous microparticles on the basis of microfluidic double-emulsion-phase droplet technique. A microfluidic chip mainly comprises a microfluidic body with micro-channels and a sealing substrate. The method includes that oil-in-water-in-oil (o / w / o) double-emulsion-phase micro-droplets are formed in the micro-channels of the microfluidic chip at first, and the double-emulsion-phase micro-droplets are polymerized into the micro-solution storage device structure containing a hydrogel shell and oil core content via photo-initiation technology; and oil cores can be slowly separated from the hydrogel shell to form the multi-phase heterogenous microparticles after the micro-solution storage device is placed under a certain dry condition.

Description

technical field [0001] The invention relates to a method for preparing a hydrogel micro-solution storage and multi-dissimilar micro-particles, and specifically provides a method for preparing a micro-solution storage and multi-dissimilar micro-particles based on a microfluidic chip double-emulsion droplet technology. Background technique [0002] Micro-solution memory is a kind of micro-memory that can store a very small amount of solution. Its characteristic size is from a few microns to hundreds of microns, and the storage capacity of the solution can range from a few picoliters to a few microliters; Microparticles of one or more different phases, which can be two different solid phases at the same time, or hybrid particles of different solid phases and liquid phases. Since various hydrogel polymers have the advantages of good biocompatibility and simple preparation, they can be used to prepare microsolution reservoirs and heterogeneous microparticles. [0003] Convention...

Claims

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Application Information

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IPC IPC(8): B81C1/00
Inventor 秦建华黄术强姜雷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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