Method for preparing micro-solution storage and multi-phase heterogenous microparticles

A memory and dissimilarity technology, applied in microstructure technology, microstructure devices, manufacturing microstructure devices, etc., can solve the problem of inability to form dual-phase or multi-phase microparticles, non-uniform microparticle size, and difficulty in achieving monodisperse characteristics and other problems, to achieve the effect of adjustable quantity, uniform particle size and controllable shape

Inactive Publication Date: 2012-10-31
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Application Information

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Problems solved by technology

Conventional methods can easily synthesize polydisperse hydrogel microparticles, but the particle size is not uniform, it is difficu

Method used

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  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles
  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles
  • Method for preparing micro-solution storage and multi-phase heterogenous microparticles

Examples

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Example Embodiment

[0026] Example 1

[0027] Preparation of hydrogel micro-solution storage containing single oil core content and two-phase and two-sided heterogeneous microparticles:

[0028] The schematic diagram of the microfluidic chip used in the preparation is as follows figure 1 Shown. Firstly, a microfluidic chip with channels on the upper layer is prepared by soft lithography technology, and then it is irreversibly sealed with the lower substrate using oxygen plasma.

[0029] The channel surface can be hydrophobized and hydrophilized to form stable double-emulsion micro-droplets. Then use an external peristaltic pump to drive different solutions by external force. The isopropyl acrylamide monomer solution enters the water phase microchannel 2, and the dispersed oil core phase (mineral oil) enters the dispersed oil core phase microchannel 1, and the continuous oil phase (FC-40) enters the continuous oil phase microchannel 3, and its flow rate is adjusted to 0.9μL / min, 0.01μL / min, 3.0μL / min, ...

Example Embodiment

[0031] Example 2

[0032] Preparation of hydrogel micro-solution storage with complex oil core content and multi-phase and multi-faceted microparticles:

[0033] The preparation of chips and various fluid control such as figure 1 As shown, when the flow rates of isopropyl acrylamide solution, mineral oil and FC-40 are 0.9μL / min, 0.03μL / min, and 3.0μL / min, two oils can be included when forming double emulsion microdroplets. The nucleus is then polymerized into a hydrogel micro-solution reservoir containing two oil-core contents. When the flow rate of mineral oil is adjusted to 0.05 μL / min, a micro-solution reservoir containing three oil-core contents can be formed. Such as Figure 4 Shown is the formation of a micro solution reservoir containing two (A to C) and three (D to F) oil core contents and the release of the oil core after adding water. Naturally dehydrating multiple inclusions at room temperature will form two-phase three-sided microparticles (such as Figure 5 A to C) a...

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Abstract

The invention provides a method for preparing a hydrogel micro-solution storage device and multi-phase heterogenous microparticles on the basis of microfluidic double-emulsion-phase droplet technique. A microfluidic chip mainly comprises a microfluidic body with micro-channels and a sealing substrate. The method includes that oil-in-water-in-oil (o/w/o) double-emulsion-phase micro-droplets are formed in the micro-channels of the microfluidic chip at first, and the double-emulsion-phase micro-droplets are polymerized into the micro-solution storage device structure containing a hydrogel shell and oil core content via photo-initiation technology; and oil cores can be slowly separated from the hydrogel shell to form the multi-phase heterogenous microparticles after the micro-solution storage device is placed under a certain dry condition.

Description

technical field [0001] The invention relates to a method for preparing a hydrogel micro-solution storage and multi-dissimilar micro-particles, and specifically provides a method for preparing a micro-solution storage and multi-dissimilar micro-particles based on a microfluidic chip double-emulsion droplet technology. Background technique [0002] Micro-solution memory is a kind of micro-memory that can store a very small amount of solution. Its characteristic size is from a few microns to hundreds of microns, and the storage capacity of the solution can range from a few picoliters to a few microliters; Microparticles of one or more different phases, which can be two different solid phases at the same time, or hybrid particles of different solid phases and liquid phases. Since various hydrogel polymers have the advantages of good biocompatibility and simple preparation, they can be used to prepare microsolution reservoirs and heterogeneous microparticles. [0003] Convention...

Claims

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Application Information

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IPC IPC(8): B81C1/00
Inventor 秦建华黄术强姜雷
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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