Traditional Chinese medicine preparation for treating heat-toxicity heart-disoperation type viral myocarditis
A technology for viral myocarditis and traditional Chinese medicine preparations, applied in antiviral agents, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve problems such as inconvenience, achieve high yield, nourish myocardium, reduce clinical use effect of dose
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preparation example Construction
[0055] The preparation method of tablet of the present invention: Ophiopogon japonicus 1500g, salvia miltiorrhiza 1200g, safflower 1000g, red peony 1500g, schisandra chinensis 1500g, astragalus 1500g, wulingzhi 1500g, atractylodes atractylodes 1500g, loofah 1500g, chuanxiong 1500g, curcuma 1500g, scutellaria baicalensis 1500g, Polygala 1000g, Angelica 1500g, Radix Radix 1100g, Folium Isatidis 1100g, Honeysuckle 1100g, Forsythia 1100g, Peppermint 1500g, Gardenia 1500g, Panax notoginseng 1500g, Earthworm 1500g plus 10 times the amount of ethanol, heated and refluxed for 3 times, each time 2 After 1 hour, the three extracts were combined, the ethanol was recovered under reduced pressure and concentrated to a concentration of 0.5 g crude drug / mL. After suction filtration, the relative density of the filtrate was about 1.08 (20° C.); Pore adsorption resin column, first eluted with deionized water or distilled water 10 times the volume of the resin column, then eluted with 95% etha...
experiment example 1
[0058] Experimental example 1: acute toxicity test of the present invention
[0059] 1. Test materials:
[0060] Animals: Kunming mice, weighing 21-24g, half male and half male, bred by Huake Biological Laboratory. Medicine: tablet of the present invention, containing 0.0425g crude drug / sheet.
[0061] 2. Method:
[0062] 1. Calculation of LD50: Using the improved Cole's method, the mice were randomly divided into 5 groups, 10 in each group, half male and half male, and the tablet was dissolved in distilled water to make the maximum concentration, and administered according to the maximum allowable volume of the mice. Dosing is followed by 18, 14.4, 11.5, 9.2, 7.4 (g.kg-1) according to the crude drug amount, and after the animal is fasted (can't help water) for 18 hours, it is divided into two administrations (interval half an hour) in one day, 0.5ml each time, observe the animal death.
[0063] 2. Determination of maximum tolerated dose (MTD value): take 20 mice, 10 males...
experiment example 2
[0066] Experimental example 2: Acute toxicity and long-term toxicity test results
[0067] Acute toxicity test: give drop pill of the present invention by intragastric administration of mice, maximum concentration 35%, maximum intragastric capacity 0.4ml / 10g, dosage 14g / kg (every g of medicinal powder is equivalent to 10g crude drug), observe continuously 7 days, No toxic reaction was found, and the LD 50 of the drug could not be measured because the concentration and dose could not be increased. Determination of the maximum tolerated dose: with the highest concentration and the maximum gavage volume, the mice were gavaged three times with an interval of 5 hours, and then observed continuously for 7 days, and no case died. The dosage of the medicinal powder is >42g / kg.day (each g of medicinal powder is equivalent to 10g of crude drug), which is equivalent to 420 times of the clinical daily dosage of an adult in terms of kilogram body weight. Long-term toxicity test: In order ...
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