Preparation method for cinnamaldehyde surface molecularly imprinted polymer

Abstract

The invention relates to a preparation method for a cinnamaldehyde surface molecularly imprinted polymer. Cinnamic acid and a cinnamic acid polymer with specific recognition characteristic are prepared by adopting a molecular imprinting technology. The molecularly imprinted polymer takes alkylated silica as a carrier, analogue cinnamic acid of cinnamaldehyde as a template, 4-vinylpyridine as a functional monomer and polyethylene glycol dimethacrylate as a cross-linking agent. The obtained molecular imprinting polymer is synthesized into trichloromethane by adopting a thermal polymerization method. The obtained molecular imprinting polymer is used as filler of a solid phase extraction column for self preparing a solid-phase extraction column with the specificity. Meanwhile, the solid-phase extraction column and liquid chromatography are combined and applied to detection of cinnamaldehyde and analogue in an actual cosmetic sample. According to the preparation method disclosed by the invention, high-efficiency separation, enrichment and purification of essence cinnamaldehyde in the cosmetics are realized; the defects of a traditional solid-phase extraction column are overcome; and the obtained solid-phase extraction column can be repeatedly used and is low in cost and favorable in application prospect.

Description

technical field [0001] The invention relates to a preparation method of a polymer imprinted with cinnamaldehyde molecules on the surface of silica gel, belonging to the fields of cosmetic detection and drug analysis. Background technique [0002] Cinnamaldehyde, commonly known as cinnamaldehyde, occurs naturally in essential oils such as Sri Lankan cinnamon oil, cassia bark oil, patchouli oil, and hyacinth oil. Due to its unique properties, it has a wide range of applications, such as medicine, chemical industry, food, flavors and fragrances, and animal feed. Cinnamaldehyde is commonly used as a flavor in cosmetics. However, with the continuous increase of cosmetics and the expansion of the scope of use, there are more and more cosmetic allergies. Cinnamaldehyde is also one of the main allergens that cause cosmetic allergies, and more and more attracted the attention of consumers. [0003] The detection methods of cinnamaldehyde mainly include liquid chromatography, gas ch...

AI Technical Summary

Problems solved by technology

Although these methods have strong specificity, they have certain disadvantages. Because the recognition site is deeply buried, it is difficult to enter and elute template molecules, so the adsorption amount is small, and the preparation method is relatively cumbersome. The emergence of surface molecular imprinting overcomes the above problems. shortcoming

Although it has been reported in the literature that the molecularly imprinted polymers prepared have good selective adsorption for pefloxacin, the methods used are basically the traditional host polymerization and precipitation polymerization methods, and these methods exist as follows The disadvantages of this method, such as the main polymerization method, the polymer prepared by it needs to be ground, this process will destroy many recognition sites, and many recognition sites are covered, the elution and adsorption of template molecules are very difficult, the specific surface area is small, and the particle size is small. Uneven diameters lead to unstable column efficiency and other phenomena

Images