Specific interaction of dentritic cell factor 1 (DCF1) genes and transmembrane protein 59 like (TMEM 59 L) genes

A TMEM59L, interaction technology, applied in recombinant DNA technology, microbial assay/inspection, biochemical equipment and methods, etc., can solve problems such as limited research
CN102776236AInactive Publication Date: 2012-11-14SHANGHAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI UNIV
Publication Date
2012-11-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to specific interaction of a dentritic cell factor 1 (DCF1) genes and transmembrane protein 59 like (TMEM 59 L) genes. Under the overexpression condition of the DCF1 and the TMEM 59 L, amyloid precursor protein (APP) can be highly and specifically inhibited from separating from golgi apparatus, the transportation of GDP dissociation inhibitor 1 (GDI1) and GDP dissociation inhibitor 2 (GDI2) are partially inhibited, the transportation of beta-site APP cleaving enzyme 2 (BACE2) protein is not inhibited, and a new drug target is provided for diagnosing and treating the Alzheimer disease.
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Description

technical field

[0001] The present invention relates to the specific interaction of DCF1 gene and TMEM59L gene. Especially the application of the interaction between DCF1 gene and TMEM59L gene in inhibiting the transportation of APP protein, GDI1 protein or GDI2 protein. Background technique

[0002] Dendritic cell factor 1 (DCF1), also known as TMEM59 (transmembrane protein 59), is Type transmembrane protein, the understanding of this protein is still not very clear. In 2008, Wang, L; et al showed by cloning, expressing, and silencing the DCF1 gene that the overexpression of DCF1 kept neural stem cells in an undifferentiated state; silencing the DCF1 gene, the cells tended to differentiate into neurons and glial cells. Through the gene chip analysis of mouse neural stem cells, the regulatory network of DCF1 was revealed, and 36 genes were inferred to be mainly involved in the regulation of DCF1, especially pou6f1 may play an important role in the transcription of DCF1 an...

Claims

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