24-dehydrocholesterol reductase coded recombinant adenoviruses specifically expressed in tissue

A technology of dehydrocholesterol and recombinant adenovirus, applied in virus/phage, biochemical equipment and method, application, etc., can solve problems such as difficulty
CN102787101AActive Publication Date: 2012-11-21LIAONING UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
LIAONING UNIVERSITY
Publication Date
2012-11-21

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Abstract

The invention relates to belongs to 24-dehydrocholesterol reductase coded recombinant adenoviruses specifically expressed in tissue, which belongs to the Alzheimer's disease gene treatment method and the treatment field. More specifically, according to the invention, by aid of a gene adenovirus carrier, the coded gene of 24-dehydrocholesterol reductase (DHCR 24) is introduced in nerve cells, the expression of 24-dehydrocholesterol protein in nerve cells is regulated, and the nerve cells protection effect can be performed. The invention also relates to a construction of defective recombinant adenoviruses for replication comprising nerve specifically expressed DHCR 24 gene and an application of the carriers in DHCR 24 gene in cells and an application of the DHCR 24 protein in nerve cells specific expression. The prepared recombinant adenoviruses are expected to obtain positive curative effect in neurodegenerative diseases such as Alzheimer's disease or other gene treatments which require a DHCR 24 supplementary therapy.
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Description

technical field

[0001] The invention relates to the field of Alzheimer's disease gene therapy and treatment. More specifically, the present invention relates to the use of genetic engineering technology to construct dhcr24 Gene replication-deficient recombinant adenoviruses, and these adenoviral vectors in the future dhcr24 Application of gene transfer into cells and realization of specific overexpression of DHCR24 protein in cells such as nerve cells. The prepared recombinant adenovirus is expected to obtain positive curative effect in the gene therapy of diseases such as Alzheimer's disease and diabetes. Background technique

[0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset, clinically characterized by memory and cognitive dysfunction, and is the most common type of senile dementia. Relevant experts predict that by 2025, 22 million people in the world will suffer from AD; it is also estimated that the market value of this treatment ar...

Claims

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