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Porous cellulose microsphere adsorbent used for blood perfusion and preparation method thereof

A technology of porous cellulose and cellulose microspheres, which is used in blood circulation treatment, chemical instruments and methods, and other chemical processes to achieve the effects of not easy to swell, not easily deform, and fast adsorption capacity

Active Publication Date: 2012-11-28
重庆希尔康血液净化器材研发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, many powdered and small cellulose microspheres on the market cannot be directly used for hemoperfusion of whole blood.

Method used

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  • Porous cellulose microsphere adsorbent used for blood perfusion and preparation method thereof
  • Porous cellulose microsphere adsorbent used for blood perfusion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Add 80g of sodium hydroxide, 10g of lithium hydroxide, 80g of urea, 50g of thiourea, 120g of polyethylene glycol 400 and 1000ml of distilled water into a three-necked flask with stirring, stir and dissolve at room temperature, then lower the temperature to - At 10°C, add 50g of dried cotton to the solution, gently stir and soak for 30 minutes, then increase the stirring speed until the cellulose is completely dissolved to form a clear and transparent solution, then vacuumize and remove air bubbles for later use.

[0029] (2) Add 100ml of Tween 80 to 4000ml of liquid paraffin and stir evenly, then lower the temperature to minus 10°C, then slowly add the oil phase to the prepared cellulose solution, while ensuring the stirring speed at 800 rpm, and slowly return to room temperature. After reacting for 30 minutes, gradually heat to 60° C. and solidify for 1.5 hours, then add dilute hydrochloric acid, let stand to separate layers, and recover the upper oil phase. The c...

Embodiment 2

[0033] (1) Add 60g of sodium hydroxide, 20g of lithium hydroxide, 60g of urea, 60g of thiourea, 100g of polyethylene glycol 400 and 1,000ml of distilled water into a three-necked flask with stirring, stir and dissolve at room temperature, then lower the temperature to - At 8°C, add 50g of dried cotton to the solution, stir gently and soak for 30 minutes, then increase the stirring speed until the cellulose is completely dissolved to form a clear and transparent solution, then vacuumize and remove air bubbles for later use.

[0034] (2) Add 90 ml of oleic acid to 5000 ml of liquid paraffin and stir evenly, then lower the temperature to minus 8°C, then slowly add the oil phase to the prepared cellulose solution, while ensuring the stirring speed at 800 rpm, and Slowly return to room temperature. After reacting for 30 minutes, gradually heat to 60° C. and solidify for 1.5 hours, then add dilute hydrochloric acid, let stand to separate layers, and recover the upper oil phase. The...

Embodiment 3

[0038] (1) Add 80g of sodium hydroxide, 30g of lithium hydroxide, 70g of urea, 50g of thiourea, 130g of polyethylene glycol 800 and 1,000ml of distilled water into a three-neck flask with stirring, stir and dissolve at room temperature, then lower the temperature to - Add 60g of dried cotton to the solution at 10°C, stir gently and soak for 30 minutes, then increase the stirring speed until the cellulose is completely dissolved to form a clear and transparent solution, then vacuumize and remove air bubbles for later use.

[0039] (2) Add 150 milliliters of Tween 80 to 5000 milliliters of liquid paraffin and stir evenly, then lower the temperature to minus 10°C, then slowly add the oil phase to the prepared cellulose solution, while ensuring that the stirring speed is at 600 rpm, and slowly return to room temperature. After reacting for 30 minutes, gradually heat to 60° C. to solidify and react for 1.5 hours, then add dilute hydrochloric acid, let stand to separate layers, and ...

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Abstract

The invention relates to a porous cellulose microsphere adsorbent used for blood perfusion and a preparation method thereof. According to the porous cellulose microsphere adsorbent, the grain sizes of prepared porous cellulose microspheres are 0.1-2mm, the inner hole sizes of the porous cellulose microspheres are mainly distributed in a range of 5nm-40nm, the specific surface area is 400-1,000m<2> / g, and the operating pressure capable of being resisted is 7-15bar. The preparation method is characterized by comprising the following steps of: obtaining the porous cellulose microspheres by utilizing an inverse suspension system, and then obtaining the porous cellulose microspheres capable of resisting the operating pressure of 7-15bar through cross linking, wherein the porous cellulose microspheres can be used as a carrier of a biomedical material or used as an adsorbent material for the blood perfusion.

Description

technical field [0001] The invention relates to the field of biomedical materials, more specifically, to a porous cellulose microsphere adsorbent for hemoperfusion and a preparation method thereof. Background technique [0002] As a method of blood purification, hemoperfusion is used in various diseases such as uremia and chronic liver disease. A core material in hemoperfusion is the porous sorbent. The adsorbent carrier for blood direct contact perfusion needs to have a certain blood compatibility and a certain pore structure. Under the joint action of functional groups, charges and other factors on the surface of the material, as well as the pore structure, it can selectively adsorb the target substance in the blood, while ensuring that the formed components of the blood are not damaged. [0003] As a medical material with good biocompatibility, cellulose has a long history of application as an adsorbent coating material for hemoperfusion or a semipermeable membrane for ...

Claims

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Application Information

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IPC IPC(8): B01J20/24B01J20/30A61M1/36
Inventor 田浩罗章凯王翔杨力张文
Owner 重庆希尔康血液净化器材研发有限公司
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