Continuous separation and purification technology for etimicin

A technology for separating and purifying etimicin sulfate, applied in the field of continuous separation and purification of etimicin sulfate, can solve the problems of large consumption of water and eluent, low purity of etimicin, low production yield and the like, Achieve the effect of high resin utilization rate, optimized purity and yield, and improved resin utilization rate

Active Publication Date: 2012-11-28
WUXI JIMIN KEXIN SHANHE PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The etimicin separated by this traditional separation method has many disadvantages such as low purity, low p...

Method used

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  • Continuous separation and purification technology for etimicin
  • Continuous separation and purification technology for etimicin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Combine below figure 1 And the embodiment is described in detail:

[0048] The selected resin of the present invention is a weakly acidic cation exchange resin, and the resin is 30 to 80 mesh, and the filling capacity of each resin tank is 0.12m 3 , the size of the resin tank is Ф350×600mm, and the actual filling ratio is 78%. The total size of the system is about 3m x 3m x 5m (length x width x height).

[0049] The disc transfer type continuous chromatographic separation system separates etimicin into the following areas:

[0050] 1) Adsorption area: (1~6 units)

[0051] There are 6 units in this area (chromatographic columns No. 1, 2, 3, 4, 5 and 6). Through flow rate control, the raw material first enters the chromatographic column group connected in parallel by No. 5 and No. 6 chromatographic columns, and then connects the remaining column units in series. The effluent from No. 1 port is waste liquid, which will be processed in the three waste center.

[0052] ...

Embodiment 2

[0070] Combine below figure 1 And the embodiment is described in detail:

[0071] The selected resin of the present invention is a weakly acidic cation exchange resin, and the resin is 30 to 80 mesh, and the filling capacity of each resin tank is 0.12m 3 , the size of the resin tank is Ф350×600mm, and the actual filling ratio is 78%. The total size of the system is about 3m×3m×5m (length×width×height).

[0072] The simulated moving bed type continuous chromatographic separation system separates etimicin sulfate into the following areas:

[0073] 1) Adsorption area: 1~6 units;

[0074] The feed liquid inlet and waste liquid outlet are located in the adsorption zone. Each unit resin tank in this area is connected in series as a group, controlled by flow rate. The raw material first enters the inlet of No. 5 and No. 6 columns, and the liquid flowing out from the outlet of No. 1 column is waste liquid.

[0075] 2) Washing area: 7 units;

[0076] After adsorption, each resin...

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Abstract

The invention relates to a continuous separation and purification method for etimicin sulfate by using the technology of continuous ion chromatography to realize high efficient separation of etimicin sulfate. The method comprises that the hydrolysate of synthesized etimicin sulfate is fed into a continuous ion chromatography system, through the steps of adsorption, removal of impurities by washing, elution of the etimicin sulfate, collection of the eluent, and regeneration of the chromatographic columns; and the etimicin sulfate is obtained through nanofiltration concentration, vacuum condensation under reduced pressure, and salt formation and decolourization of the collected eluent. By using the method for separation and purification, the obtained etimicin are of high yield and purity, low cost, and environmental protection, suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of semi-synthetic chemical pharmacy, and relates to a method for continuous separation and purification of etimicin sulfate. The method utilizes disc-transfer continuous chromatography or simulated moving bed continuous chromatography to separate and purify etimicin sulfate from etimicin hydrolyzate. The tilmicin method. After separation and purification, nanofiltration membrane technology is used to reduce the generation of degradation products of etimicin by controlling the temperature conditions of the purification process. It belongs to the field of continuous chromatographic separation and purification of organic compounds combined with membrane concentration technology. Background technique [0002] Etimicin sulfate, the structural formula is as follows: [0003] [0004] Chemical name 2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4-amino-3-((2R,3R,6S)-3-amino-6-(a minomethyl )tetrahydro-2H-pyran-2-yloxy)-6-(ethylamino...

Claims

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Application Information

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IPC IPC(8): C07H15/236C07H1/06
CPCY02P20/582
Inventor 邹济高姜迎庆王云龙郭永忠刘凤珍聂昌胜
Owner WUXI JIMIN KEXIN SHANHE PHARMA
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