Cooling gel sheet

A cooling patch and temperature-sensitive technology, applied in the direction of heating appliances for treatment, cooling appliances for treatment, contraceptives, etc., can solve eye and wound irritation, reduce temperature and protect brain cells, and increase patient use Cost and other issues, to achieve the effect of rapid response to temperature sensitivity, easy to accept treatment, and good biocompatibility

Inactive Publication Date: 2012-12-19
安徽安生生物化工科技有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many defects in the existing cooling patch products at present, such as the cooling time is generally short, generally about 2-3 hours, and can only be used once, which virtually increases the cost of use for patients; most of the existing cooling patches are added Mint, borneol and other traditional Chinese medicine ingredients are used to assis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Dissolve 0.4 g of hydroxypropyl methylcellulose and 8.0 g of acrylic acid in 90 ml of distilled water, then add 0.35 g of potassium persulfate, fill it with nitrogen, raise the temperature to 38°C, and add 0.35 g of it after preheating for 10 minutes N'N-methylenebisacrylamide, stirred for 5 hours to get the concentrated solution of Nagel; then take 4.5 g of polyvinyl alcohol (polymerization degree 1950) and 0.65 g of pregelatinized starch dissolved in 75 ml of distilled water, after completely dissolving, take 25 ml of concentrated nanogel solution and add it to the solution, after a little cooling, pour it into a mold and put it in a freezer (-15°C) to freeze for 2.5 hours and then thaw, cycle 2 times, A hydrogel cooling patch containing nanogel was obtained.

[0037] figure 2 For the cooling effect diagram - use a constant temperature heating plate to simulate the temperature of the human body to test the cooling effect, place the cooling patch on the co...

Embodiment 2

[0039] Example 2. Dissolve 0.45 g of hydroxypropylmethylcellulose and 7.2 g of acrylic acid in 90 ml of distilled water, then add 0.4 g of potassium persulfate, fill with nitrogen, raise the temperature to 38°C, preheat for 10 minutes, then add 0.4 g N'N-methylenebisacrylamide, stirred and reacted for 6 hours to obtain the concentrated solution of the gel; then take 4.8 g polyvinyl alcohol (polymerization degree 1800) and 0.8 g pregelatinized starch dissolved in 70 ml of distilled water, after completely dissolving, take 25 ml of concentrated nanogel solution and add it to the solution, after cooling down slightly, pour it into a mold and put it in a freezer (-20°C) to freeze for two hours and then thaw, cycle twice, A hydrogel cooling patch containing nanogel was obtained.

[0040]

Embodiment 3

[0041]Example 3: Dissolve 0.4 g of hydroxypropylmethyl cellulose, 0.35 g of maleic anhydride and 8.0 g of acrylic acid mixed solution in 90 ml of distilled water, then add 0.35 g of ammonium persulfate, fill with nitrogen, and the temperature rises to 38 ℃, stirred and reacted for 5 hours to obtain the concentrated solution of Nagel; then take 5 g of polyvinyl alcohol (polymerization degree of 1750) and 0.6 g of pregelatinized starch dissolved in 75 ml of distilled water with the assistance of microwave, after completely dissolved, take Add 25 ml of concentrated nanogel solution into the solution, after a little cooling, pour it into a mold and put it in a freezer (-12°C) for 3 hours, then thaw, and cycle 3 times to get a hydrogel containing nanogel Cooling stickers.

[0042]

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PUM

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Abstract

The invention discloses a cooling gel sheet which comprises the following components in percentage by weight: 1 to 3% of acrylic acid, 0.05 to 0.3% of non-ionic cellulose ether with thermosensitivity, 3 to 6% of polyving akohol, 0.3 to 1% of pregelatinized starch, 0.05 to 0.3% of cross-linking agent, 0.05 to 0.3% of initiator, and the balance of water. The cooling gel sheet disclosed by the invention has quickly responding thermosensitivity, so an effect of quickly cooling can be achieved. The cooling gel sheet is safe and reliable, and plays a function by completely depending on physical cooling.

Description

technical field [0001] The invention belongs to the field of medical chemical compositions, in particular to a cooling patch. Background technique [0002] There are mainly two kinds of cooling measures commonly used in clinic, one is physical cooling, and the other is drug cooling. Which cooling method should be used should be decided according to the patient's age, constitution and fever degree. Drug cooling has the advantages of obvious effect and simple method of use. In clinical practice, currently commonly used antipyretic and analgesic drugs include aspirin (acetylsalicylic acid), paracetamol (acetaminophen), indomethacin (indomethacin), ibuprofen, etc., but the side effects of these drugs have amazing or irreversible damage to the liver, kidney and digestive tract of children, and there are many contraindications for drug cooling, such as: patients with a history of allergy to antipyretic drugs should not Fever drugs; patients with allergies should also be cautious...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L1/28C08L1/26C08L3/04C08J3/28C08J3/24C08F220/06A61F7/02
Inventor 姚日生张维博邓胜松张遥姚力蓉
Owner 安徽安生生物化工科技有限责任公司
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