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Hollow capsule and preparation method thereof

A hollow capsule and glue-dipping technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, can solve the problems of lack of market development prospects, low product quality qualification rate, and unstable production processes, and achieves the application of Wide range, improve the pass rate, easy to promote the effect of large-scale application

Active Publication Date: 2012-12-26
青岛晓丛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the plant empty capsule market in my country is completely occupied by foreign brands. Although my country has a number of plant empty capsule formulas and production patents, there are few reports on the products that have actually been produced on a large scale and put on the market. The main reason is that the product formula is complex, Unstable production process, low pass rate of product quality and other reasons make it lack of market development prospects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Based on 1 kg of water, the proportion of the hollow capsule in this example is as follows: 30 grams of κ-carrageenan, 150 grams of water-soluble potato cross-linked starch, 20 grams of glycerin, 0.5 grams of preservatives and 0.5 grams of food coloring. The preparation method is as follows:

[0035] Sol: Fill the sol tank with hot water at 70-90°C, then add κ-carrageenan and potato cross-linked starch into the sol tank during stirring, and add plasticizer glycerin, preservatives and food coloring. to dissolve completely;

[0036] Glue cultivation: After the glue is stirred evenly, stop stirring, cool down to 40-45°C, then keep warm at 40-45°C and let it stand for 30-60min, then put the glue into the glue dipping tank;

[0037] Glue dipping: when the temperature of the glue liquid in the glue dipping tank drops to 35°C, the capsule template is automatically glued, dried (until the water content is less than 10% of the weight of the hollow capsule), shelled, c...

Embodiment 2

[0039] Example 2 Based on 1 kg of water, the proportion of the hollow capsule in this example is as follows: 20 grams of κ-carrageenan, 100 grams of water-soluble potato cross-linked starch, 40 grams of glycerin, 3 grams of preservatives and 3 grams of food coloring. Production method is the same as example 1.

[0040] After 10 times of remelting in this example, the indicators and properties of the prepared hollow capsules are shown in Table 1. It can be seen that the indicators and properties of the capsule are not significantly affected after 10 times of remelting, indicating that the formula of this embodiment can be used for multiple remelting.

Embodiment 3

[0041] Embodiment 3 According to 1 kilogram of water, the proportion of the empty capsule of the present embodiment is as follows: 20 grams of κ-carrageenan, 15 grams of ι-carrageenan, 110 grams of water-soluble potato cross-linked starch, 20 grams of glycerin, and 2 grams of preservatives and food coloring 2 grams.

[0042] The preparation method is as follows:

[0043] Sol: Fill the sol tank with hot water at 70-90°C, then add κ-carrageenan, iota-carrageenan and potato cross-linked starch into the sol tank during stirring, add plasticizer glycerin, preservatives and food coloring . to dissolve completely;

[0044] Glue cultivation: After the glue is stirred evenly, stop stirring, cool down to 40-45°C, then keep warm at 40-45°C and let it stand for 30-60min, then put the glue into the glue dipping tank;

[0045] Glue dipping: when the temperature of the glue liquid in the glue dipping tank drops to 35°C, the capsule template is automatically glued, dried (until the water c...

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Abstract

The invention discloses a hollow capsule, which comprises the following components in parts by weight: 10 to 30 parts of kappa-carrageenan, 90 to 180 parts of water-soluble crosslinked starch, and 20 to 40 parts of plasticizer. The invention also discloses a preparation of the hollow capsule, which comprises the following steps of: 1) dissolving gum, wherein carrageenan and water-soluble crosslinked starch are stirred, water at a temperature of between 70 and 90 DEG C is added into the mixture, the plasticizer in the amount of the prescription is added and completely dissolved, and the mixture is stirred uniformly; 2) culturing the gum, wherein the gum liquid obtained in the step 1) is cooled to a temperature of between 40 and 45 DEG C, the gum liquid is insulated and stood for 30 to 60 minutes, and the gum liquid is put into a gum soaking tank; and 3) soaking the gum, wherein when the temperature of the gum liquid in the gum soaking tank is cooled to 35 DEG C, operations of gum soaking, drying, shell pulling out, cutting and buckling are automatically carried out through a capsule template. According to the hollow capsule disclosed by the invention, the transparency and toughness are remarkably improved, the friability is remarkably reduced, and the product yield is greatly increased.

Description

technical field [0001] The invention relates to a hollow capsule and a preparation method thereof. Background technique [0002] Hard-shell hollow capsules for medicines and health care products are special excipients. It enters the digestive system of the human body together with the preparation and is absorbed by the human body, so its quality standard and safety are directly related to the quality and safety of finished medicines and health food products. Animal gelatin has always maintained its position as the mainstream capsule material for hollow capsules due to its natural advantages such as a wide range of raw material sources, stable physical and chemical properties, and excellent processing performance. However, in the long-term use process, many potential quality and safety problems of gelatin hollow capsules are becoming more and more obvious. Especially in recent years, the frequent occurrence of foot-and-mouth disease and mad cow disease in European and Ameri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36
Inventor 刘超中许鹏
Owner 青岛晓丛生物科技有限公司
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