Compound buccal tablet

A buccal tablet and compound technology, applied in the field of medicine, can solve the problems of unavoidable liver first-pass effect, throat diseases cannot reach the lesions, low bioavailability, etc., to avoid first-pass effect, improve bioavailability, suitable for The effect of mass production

Inactive Publication Date: 2012-12-26
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The components of these products are complex, difficult to quality control, difficult to avoid the first-pass effect of the liver

Method used

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  • Compound buccal tablet
  • Compound buccal tablet
  • Compound buccal tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]

[0035] Preparation method: take andrographolide, sirutin, mannitol, lactose, and aspartame and mix them uniformly in equal amounts, then make soft material with water, granulate, dry at 60°C, granulate, add stearin Magnesium acid, mixed evenly, and then compressed into tablets.

[0036]

Embodiment 2

[0038]

[0039] Preparation method: take andrographolide, sirutin, mannitol, lactose, sucrose, and aspartame and mix them uniformly in equal amounts, then make soft materials with water, granulate, dry at 60°C, granulate, add Magnesium stearate, mixed evenly, and compressed into tablets.

Embodiment 3

[0041]

[0042] Preparation method: take andrographolide, sirutin, mannitol, lactose, sucrose, and aspartame and mix them uniformly in equal amounts, then make soft materials with water, granulate, dry at 60°C, granulate, add Magnesium stearate, mixed evenly, and compressed into tablets.

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PUM

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Abstract

The invention discloses a compound buccal tablet, which is prepared by adding medicinal adjuvants into daphnoretin and andrographolide as active ingredients, wherein the weight ratio of daphnoretin to andrographolide is 1 to (0.5-8). The buccal tablet can directly reach up to the focuses when the relevant diseases in a throat part are treated, the buccal tablet can be placed at the hypogloeeis or between the gum and the cheek so as to be absorbed through the mouth mucosa or the hypoglossal mucosa, so that the first-pass effect caused by the liver can be effectively avoided when the buccal tablet is taken, and the bioavailability of the buccal tablet can be greatly improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a compound buccal tablet with sipratin and andrographolide as active ingredients. Background technique [0002] In recent years, due to the decline of air quality and the accelerated pace of life, the incidence of throat diseases has been increasing year by year, and has become a major factor that endangers human health. When the throat is affected, it not only seriously affects people's normal breathing, swallowing and talking, but also makes it easy for virus bacteria to invade the lungs and cause bronchitis and pneumonia, damage the lymphatic tissue, lead to decreased immunity and cause other physical diseases, seriously damaging human health. [0003] Judging from the current treatment status, the treatment of throat diseases is generally Western medicine, which uses antibacterial and anti-inflammatory drugs, and antibiotics are often used in drugs, which can ea...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61K9/20A61P11/04A61P31/04A61P31/12A61K31/365
Inventor 陈燕忠王定勇喻文进肖玥徐祖疆
Owner GUANGDONG PHARMA UNIV
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