Substituted phenyl acetate compound and application thereof

Abstract

The invention belongs to the fields of medicine and chemistry, and provides a substituted phenyl acetate compound with the structure shown by formula (I), which has short-acting sedative-hypnotic effect so as to be used for preparing anesthetic and sedative. The experiments prove that the substituted phenyl acetate compound has the anesthetic activity stronger than that of propanidid, and has the action time and the recovery time which are shorter and more foreseeable than those of propofol, thus having the characteristics of being high in anesthetic effect and medicine effect, low in toxic and side effects and the like.

Description

technical field

[0001] The invention belongs to the fields of medicine and chemistry, and relates to substituted phenyl acetate compounds, which can be used as short-acting sedative hypnotic agents for anesthesia and sedation. The invention also relates to pharmaceutical compositions comprising such compounds; methods of inducing or maintaining anesthesia or sedation using such compounds. Background technique

[0002] Propofol, 2,6-diisopropylphenol, is an injectable anesthetic with hypnotic properties. It can be used to induce and maintain general anesthesia and sedation. The action time of propofol after infusion is unknown, and this unpredictable action duration leads to irregular recovery time of patients, and most patients have long recovery time and poor controllability. In addition, propofol has cardiovascular side effects and produces pain reactions when injected.

[0003] Propanidid, [4-[(N,N-ethylcarbamoyl)methoxy]-3-methoxyphenyl]propyl acetate, is another inje...

Images