Application of apigenin on preparation of medicine for treating pneumonia

A technology of apigenin and pneumonia, applied in the field of medicine, can solve problems such as treatment failure

Active Publication Date: 2013-01-16
SHANDONG JINZHUJI PHARM CO LTD +1
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Problems solved by technology

Current drugs for the treatment of Staphylococcus aureus pneumonia usually use oxa...

Method used

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  • Application of apigenin on preparation of medicine for treating pneumonia
  • Application of apigenin on preparation of medicine for treating pneumonia

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Experimental program
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Embodiment Construction

[0007] 1. Hemolysis test

[0008] Different concentrations of apigenin were co-cultured with Staphylococcus aureus until late logarithmic growth, and the bacterial supernatant was collected by high-speed centrifugation. Take 100 μL of bacterial supernatant, 875 μL of PBS and 25 μL of defibrinated rabbit red blood cells, mix evenly, incubate at 37°C for 15 min, and observe the changes in the hemolytic activity of the bacterial supernatant treated with different concentrations of apigenin. The hemolysis ratio was calculated using the bacterial supernatant without apigenin as a control.

[0009] Table 1. The effect of apigenin on the hemolytic activity of Staphylococcus aureus α-hemolysin

[0010] Apigenin (μg / ml)

Hemolysis ratio (%)

0

100

1

78.14

2

52.24

4

11.06

8

3.11

[0011] 2. Protection test of human lung epithelial cells (A549) injury

[0012] Staphylococcu...

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Abstract

The invention relates to an application of apigenin on preparation of a medicine for treating pneumonia. A therapeutical effect of the apigenin on staphylococcus aureus infection is proved by a rabbit red blood cell haemolysis test, a protection test of human pulmonary epithelial cells (A549) damage and a mice staphylococcus aureus pneumonia model. Compared with an antibiotic therapy, a therapy applying the apigenin has the characteristics of no drug tolerance and high cure rate.

Description

technical field [0001] The invention relates to the application of apigenin in the preparation of medicines for treating pneumonia, belonging to the field of medicine. 1. Background Technology [0002] Apigenin (Apigenin) is a flavonoid compound extracted and isolated from plants such as Umbelliferae celery. Both diplococcus and meningococcus have inhibitory effect, and the minimum inhibitory concentration (MIC) is between 64-256 μg / ml. But so far, there are no reports of apigenin being used in the treatment of bacterial pneumonia at home and abroad. [0003] Bacterial pneumonia is a disease caused by infections such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, Legionella, etc. The mortality rate of this disease is extremely high in children, the elderly and immunocompromised patients. In recent years, the extensive use of antibiotics has led to an increase in the rate of bacterial resistance, making the treatment of b...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P11/00A61P31/04A61P31/10
Inventor 邓旭明董靖邱家章谭为
Owner SHANDONG JINZHUJI PHARM CO LTD
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